88-50100506 Scientist 2
Apply NowCompany: Roche
Location: South San Francisco, CA 94080
Description:
The Position
Genentech, Inc. seeks a Scientist 2 in its South San Francisco, California location.
Duties: Design and plan experimental studies that effectively compare, contrast, and rank order candidate drug molecules, and elucidate critical Pharmacokinetic (PK)/Pharmacodynamic (PD) parameters required to build effective PK/PD models. Design and execute in vivo experiments (i.e., experiments in pre-clinical animal species) by handling, dosing, and performing tissue harvest, using standard dosing techniques to administer candidate drugs, as well as highly specialized dosing techniques to model inhaled drug delivery; and collecting and processing of tissue samples for in vivo measurements and readouts. Perform the above using intravenous (IV); oral gavage (PO, delivering dose directly to the esophagus and stomach of animals); intraperitoneal (injection into the space between organs in the abdomen); intra-nasal/intra-tracheal; subcutaneous (SC/SQ); and other routes of administration. Execute experiments via sterile sample handling and pipetting, while utilizing knowledge of concentrations and dilutions in liquid buffers and formulations, sample processing, and use of commercial kits for DNA/RNA extraction from samples or for detection of specific protein levels in samples. Model inhaled drug delivery with dry or wet aerosols in pre-clinical rodent species. Analyze, interpret, communicate, and document data obtained from completed experiments. Perform analysis of data from the experiments, including calculations, graphing, and statistical analysis. Telecommuting is permitted 10% of the time.
Education and experience required: Bachelor's degree, or foreign equivalent, in Immunology, biology, cell biology, neuroscience, genetics, biochemistry, or a closely related field and 1 year of experience as Research Assistant, Research Associate, Scientist, or a closely related occupation or related position.
Special Requirements: Must have one year of experience with the following:
The expected salary range for this position based on the primary location for this position of South San Francisco, California is $114,168 to $148,500 per year. Actual pay within the range will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (https://roche.ehr.com/default.ashx?CLASSNAME=splash)
Worksite: 1 DNA Way, South San Francisco, CA 94080
Who we are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Genentech, Inc. seeks a Scientist 2 in its South San Francisco, California location.
Duties: Design and plan experimental studies that effectively compare, contrast, and rank order candidate drug molecules, and elucidate critical Pharmacokinetic (PK)/Pharmacodynamic (PD) parameters required to build effective PK/PD models. Design and execute in vivo experiments (i.e., experiments in pre-clinical animal species) by handling, dosing, and performing tissue harvest, using standard dosing techniques to administer candidate drugs, as well as highly specialized dosing techniques to model inhaled drug delivery; and collecting and processing of tissue samples for in vivo measurements and readouts. Perform the above using intravenous (IV); oral gavage (PO, delivering dose directly to the esophagus and stomach of animals); intraperitoneal (injection into the space between organs in the abdomen); intra-nasal/intra-tracheal; subcutaneous (SC/SQ); and other routes of administration. Execute experiments via sterile sample handling and pipetting, while utilizing knowledge of concentrations and dilutions in liquid buffers and formulations, sample processing, and use of commercial kits for DNA/RNA extraction from samples or for detection of specific protein levels in samples. Model inhaled drug delivery with dry or wet aerosols in pre-clinical rodent species. Analyze, interpret, communicate, and document data obtained from completed experiments. Perform analysis of data from the experiments, including calculations, graphing, and statistical analysis. Telecommuting is permitted 10% of the time.
Education and experience required: Bachelor's degree, or foreign equivalent, in Immunology, biology, cell biology, neuroscience, genetics, biochemistry, or a closely related field and 1 year of experience as Research Assistant, Research Associate, Scientist, or a closely related occupation or related position.
Special Requirements: Must have one year of experience with the following:
- Routine lab animal handling, in vivo work with preclinical animal models of disease and pharmacokinetics/pharmacodynamics (PK/PD);
- Rodent dosing standard methods and inhalation specialized dosing (e.g., of allergens, immune stimulants such as bacterial components, or drug candidate molecules) using a subset of standard dosing routes: intravenous, intraperitoneal, oral gavage, and/or subcutaneous;
- Rodent blood and tissue collection;
- Experimental design and planning to answer questions for basic research as well as drug development, including appropriate inclusion of controls, realistic assessment of logistical limitations, and coordination of resources and activities across collaborating departments;
- Downstream processing and analysis of samples obtained from animal experiments, such as pathology techniques (tissue fixation/embedding/sectioning, tissue staining, immunohistochemistry, immunofluorescence), biochemistry techniques (western blot, immunoprecipitation, electromobility shift assay), immunological assays (fluorescence activated cell sorting, enzyme-linked-immunosorbent assay, enzyme-linked immunosorbent spot), in vitro cell assays (cell culture, in vitro cell stimulation, cell-cell interaction), or molecular biology (polymerase chain reaction, real-time-quantitative PCR, DNA/RNA isolation/purification);
- Analyzing and summarizing data obtained from experiments performed in order to understand, interpret, and share the outcome;
- Scientific presentation and communication of experimental data to cross-functional audience (e.g., lab, internal and external collaborators, project teams), both verbally and in written forms.
The expected salary range for this position based on the primary location for this position of South San Francisco, California is $114,168 to $148,500 per year. Actual pay within the range will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (https://roche.ehr.com/default.ashx?CLASSNAME=splash)
Worksite: 1 DNA Way, South San Francisco, CA 94080
Who we are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.