Advisor, Medicinal Chemistry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary:

We are seeking a Medicinal Chemistry Scientist to join our Discovery and Preclinical R&D team. The successful candidate will have a strong background in small molecule and peptide synthesis and will leverage these skills to advance new ligands for targeted radiopharmaceuticals. A strong understanding in drug discovery, microbiology/biochemistry assay analysis, analytical chemistry, and animal model DMPK is also important.

Responsibilities:

• Support POINT's early targeted radiopharmaceuticals drug discovery efforts.
• Independently plan and carry out the synthesis, purification, and characterization of target molecules, including small molecule ligands and oligopeptides.
• Perform routine maintenance on laboratory equipment.
• Coordinating and collaborating with external (CRO's) and internal groups across CMC, preclinical, DMPK, etc.
• Participate in study design, vendor selection, study execution, interpretation and report writing.
• Facilitate preparation, packaging, and shipping of materials to other POINT facilities and external partners.
• Work with chemists and logistics teams to source, purchase, and monitor ships of commercial chemicals.
• Generate and manage internal documentation involve chemical structure and characterization databases.
• Work collaboratively with teams of diverse scientific expertise and clearly communicate experimental details and scientific results.
• Demonstrate flexibility in day-to-day operations, assisting other divisions in R&D.

Basic Requirements:

• PhD in organic chemistry, medicinal chemistry, or related fields
• 2+ years relevant post-graduate experience in synthetic chemistry
• Experience with small molecule organic synthesis and design of reactions
• Experience in normal and reverse phase chromatography
• Ability to analyze composition and purity of products (NMR, HPLC, MS, etc.)
• Experience with multi-step organic synthesis and characterization w/ working knowledge of solid-phase peptide synthesis
• Working knowledge of MS-Office, ChemDraw, MestreNova

Additional Preferences:

• 2+ years of industry experience
• Experience working with radioligand therapy or molecular imaging
• Understanding of medicinal chemistry, microbiology, biochemistry, and PK/PD principles
• Solid understanding and experience with peptide synthesis
• Capable of working independently and managing time effectively
• Excellent problem solving and decision-making skills
• Excellent oral and written communication skills, with the ability communicate scientific results to an interdisciplinary team

Additional Information:

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment

• Work environment is onsite downtown Toronto near College Street and University Avenue at the MaRS building.
• Anticipate travel for team and client meetings. Traveling across borders may be required, proper travel documentation such as a valid passport and travel visas are required.
• Wearing standard PPE in the lab is required.
• Must have use of full dexterity to perform routine benchwork in a laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position's work environment is in a laboratory.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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