Associate Principal Scientist, Imaging
Apply NowCompany: Merck & Co, Inc
Location: West Point, PA 19486
Description:
Job Description
The Translational Imaging team at our Company's Research Laboratories in West Point, PA is seeking a talented Associate Principal Scientist to support the discovery and qualification of novel positron emission tomography (PET) tracers with their expertise in the application of radioligand binding assays. This Associate Principal Scientist will work in a collaborative research environment to support drug discovery programs across multiple therapeutic areas, with a focus on neuroscience and oncology.
Responsibilities:
Qualifications:
Education:
Required Experience and Skills:
Preferred Experience and Skills:
#EligibleforERP
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
YES
Job Posting End Date:
06/30/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
The Translational Imaging team at our Company's Research Laboratories in West Point, PA is seeking a talented Associate Principal Scientist to support the discovery and qualification of novel positron emission tomography (PET) tracers with their expertise in the application of radioligand binding assays. This Associate Principal Scientist will work in a collaborative research environment to support drug discovery programs across multiple therapeutic areas, with a focus on neuroscience and oncology.
Responsibilities:
- Design, optimize and perform in vitro radioligand binding assays, including autoradiography and tissue homogenate binding assays, to assess the binding characteristics of radioligands to support PET tracer discovery and development
- Analyze, interpret results and draw conclusions from experiments, and suggest, design, and pursue relevant experiments
- Generate reliable and reproducible data in a timely manner
- Present results and next steps at group meetings and project meetings
- Access and understand relevant scientific literature and apply theoretical framework to solving problems within scientific discipline in a timely manner.
- Work effectively with other scientists as part of a collaborative, multidisciplinary team
Qualifications:
Education:
- Master's (with 8+ years) or Ph.D. in biology, pharmacology, radiopharmaceutical sciences or related field and relevant work experience in the area of radiopharmaceutical discovery
Required Experience and Skills:
- Design, optimization, and implementation of radioligand binding experiments in tissue homogenate
- Design, optimization, and implementation of autoradiography experiments on tissue slices
- Sectioning of frozen tissue for autoradiography experiments
- Ability to independently design, execute and interpret in vitro radioligand binding experiments
- Analysis and interpretation of data from in vitro binding experiments using graphical nonlinear curve fitting software methods
- Theoretical knowledge of ligand-receptor binding interactions and their application to drug discovery
- Proven track record of generating publication quality data and contributing to manuscript or patent preparation.
- Highly developed oral and written communication skills and keen ability to engage internal and external team members in collaborative research
- Self-motivated and resourceful with good interpersonal skills
- Ability to independently manage workflow to see projects through from start to completion
- Strong interpersonal, verbal and written communication skills
- Willingness and ability to work with radioactive materials including H, 18F, and/or 89Zr.
- Strong record keeping skills
- Demonstrates a high level of attention to detail
Preferred Experience and Skills:
- Experience with molecular biology assays such as Western blot, ELISA, etc.
- Immunohistochemistry and/or immunofluorescence staining experience
#EligibleforERP
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
YES
Job Posting End Date:
06/30/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.