Chemical Biology Research Scientist

We are seeking a Chemical Biology Research Scientist. Our mission is to develop treatments for serious diseases, including those with traditionally difficult-to-drug targets. In this lab-based role, the scientist will apply novel covalent drug discovery techniques to identify and validate ligands for challenging proteins. The ideal candidate is a motivated, detail-oriented, and lifelong learner with expertise in covalent drug discovery and compound screening.

Key Responsibilities:

• Conduct high-throughput compound screening.
• Design, execute, and troubleshoot novel screening approaches for covalent ligand discovery.
• Proactively communicate verbally and in writing to engage effectively with multidisciplinary team members.
• Collaborate with team members to coordinate screening stages and timelines.

Knowledge and Skills:

• Expertise in covalent chemoproteomics and data analysis.
• Strong understanding of compound binding affinity, selectivity, reactivity, and kinetics.
• Experience with automation for liquid handling.
• Proficiency in affinity capture methods, including immunoprecipitation.
• Experience with Western blot analysis.
• Strong background in cell biology, including cell culture and lentiviral-based expression.

Requirements

Education and Experience:

• Ph.D. in Chemistry, Biochemistry, Chemical Biology, or a related field; or
• Master's degree with at least 3 years of relevant experience.
• Hands-on experience in covalent drug discovery, compound screening, and biochemical assays.
• Strong track record of scientific research and problem-solving in a laboratory setting.