Scientist, mRNA

At Providence Therapeutics, we Ignite the Cure Within. We are a clinical stage Canadian mRNA company focusing on getting the best quality vaccines to the places that need it most. These include infectious diseases and cancer. We are on the leading edge of vaccine development and are on the hunt for people with an adventurous mindset to join us. We want to make a difference and help heal the World.

We have an immediate opening for a Scientist, mRNA. This position is available in Calgary, AB.

How we plan on keeping you busy:

• Produce technical reports, presentations, and other documents related to process development, experimentation, qualification, and validation

• Contribute to the design and execution of process optimization and development studies

• Assess the robustness of the mRNA production process with small-scale studies

• Assess small-scale models for process representativeness

• Develop small-scale production processes designed to meet standardized quality and performance indicators for new mRNA constructs

• Support technology transfer efforts by providing technical insights and responding to partner requests regarding the mRNA production process

• Mentor junior team members, providing technical guidance and supporting their development in mRNA research

• Other duties as assigned.

What will help you get here:

• PhD in Biochemistry/Molecular Biology/Chemical Engineering/Biophysics or closely related field
• Experience in design, QC, and testing of mRNA-based therapeutics with thorough knowledge of mRNA structure and function
• Experience, with hands-on expertise in in vitro transcription, purification, and nucleic acid assay development (e.g., RT-qPCR, CGE)
• Knowledge of preparative chromatographic purification, including mRNA purification and UFDF
• Demonstrated experience in the process development of biological pharmaceutical products
• Knowledge of GMP regulations and guidance for process development, qualification, and validation would be an asset
• Familiarity with CMC regulatory documents; past contributions to CMC sections of regulatory submissions (IMPD, IND, BLA)
• Knowledge of generating libraries for RNA sequencing (such as mRNA-seq, CLIP-seq, etc.) and next-generation sequencing is a plus
• Strong verbal and written communication skills.
• Effective interpersonal skills

Working Conditions

• • Must adhere to proper PPE (Personal Protective Equipment) use when working in the lab
  • 40 hours per week, Monday to Friday
  • Works in an office-based environment using technology for extended periods

What it's like to work with us:

At Providence Therapeutics, you'll be working with a clinical Canadian Biotech company that is innovating in the fast-growing mRNA space. We are focused on helping and healing people around the world. We are looking for culture builders and visionaries to help us make our infectious disease and cancer programs a reality. You truly have an opportunity to have a positive impact on individuals' lives.

What you can expect working with us:

• Competitive salary and flexible benefits package
• Flexible and remote work
• Unlimited vacation and Providence Wellness Days