Scientist, Phage Display & Discovery

Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics.Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position

We are seeking an exceptional scientist with expertise in library-based methodologies and substantial wet-lab experience to join our team. In this role, you will lead comprehensive library-based projects from conception to completion, engineering therapeutic proteins with transformative potential. You will develop and execute novel high-throughput screening assays, design and construct DNA libraries using advanced cloning techniques, and analyze complex library screens, including massively parallel in vivo screens powered by our proprietary mCode protein barcoding technology. You will work with a highly interdisciplinary team of creative experimental, computational, and hybrid scientists to advance high-throughput protein engineering and synthetic biology initiatives. As a key member of our growing company, you will contribute to building a culture that embraces scientific boldness and a strong team-focused approach to solving problems.

Required Qualifications:

Wet Lab Expertise:

• Masters/PhD or equivalent experience in molecular biology, bioengineering, or a related field.
• Proficiency in standard molecular biology techniques and protocols.
• Hands-on experience with display-based approaches such as phage.
• Experience designing and constructing diverse DNA libraries for protein engineering applications.
• Proven capability in library-based protein engineering, including experience with high-throughput or multiplexed assay formats.
• Skilled in designing, executing, and analyzing complex experimental workflows from end to end.

Core Competencies:

• Detail-oriented with exceptional organizational and communication skills.
• Curious and flexible, with a strong desire to work collaboratively within a fast-paced and multidisciplinary team environment.
• A love for tinkering with biological parts and solving challenges to develop novel assays.
• Enthusiasm for combining rational design with unbiased approaches to problem-solving.

Preferred Qualifications:

• 2+ years of start-up, biotech, or pharma experience in protein engineering or assay development.
• Direct experience with display technologies and selections including phage, yeast, and/or ribosome display.
• Hands-on experience with Next Geneneration Sequencing (NGS).
• Experience with handling/processing animal tissues.
• Experience developing or engineering brain shuttle technologies for improved blood-brain barrier transport.
• Familiarity with screening-based methods with an NGS readout, e.g. DMS, MPRA, CRISPR screening, cancer screens, single cell sequencing.
• Experience with data analysis (Python or R).

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.