Scientist/Sr. Scientist, Discovery Screening
Apply NowCompany: Flagship Pioneering
Location: Dorchester Center, MA 02124
Description:
Company Overview:
Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of SynteinsTM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular scientists who are passionate about driving chemical innovation in biotechnology. Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Seres Therapeutics (NASDAQ: MCRB) and Generate Biomedicines were conceived and created.
Position Summary:
We are looking for a highly motivated, experienced cell biologist and assay development/screening scientist to join our growing team. In this role, the successful candidate will be responsible for developing and executing novel cell-based screening assays to drive the Abiologics SynteinTM discovery platform. This role will serve as the cell biology lead/expert within the Discovery team and will have the opportunity to collaborate cross-functionally with a diverse team across Abiologics to impact platform and company build-out.
Key Responsibilities:
Qualifications:
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
About Flagship Pioneering:
Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of SynteinsTM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular scientists who are passionate about driving chemical innovation in biotechnology. Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Seres Therapeutics (NASDAQ: MCRB) and Generate Biomedicines were conceived and created.
Position Summary:
We are looking for a highly motivated, experienced cell biologist and assay development/screening scientist to join our growing team. In this role, the successful candidate will be responsible for developing and executing novel cell-based screening assays to drive the Abiologics SynteinTM discovery platform. This role will serve as the cell biology lead/expert within the Discovery team and will have the opportunity to collaborate cross-functionally with a diverse team across Abiologics to impact platform and company build-out.
Key Responsibilities:
- Design, develop and execute cell-based screening assays to assess SynteinTM activity, target engagement and mechanism of action to drive discovery programs
- Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas
- Collaborate within Discovery team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
- Collaborate cross-functionally with Chemistry, Platform Development and In vivo biology teams to enable novel methods, assays and screening workflows
- Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teammates to drive design-make-test cycles
- Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings
Qualifications:
- PhD in molecular or cell biology or related discipline with minimum 2 years relevant experience in industry required
- Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, and reporter cell lines
- Proficient in industry-standard cell-based assay and bioanalytical techniques including TR-FRET, ELISA, flow cytometry, and reporter gene; experience with cellular/high content imaging and image analysis highly desirable
- Demonstrated ability to independently design, develop and optimize diverse cell-based assays and interpret complex results
- Disease biology expertise in immunology, oncology, or neurobiology a plus
- Proficiency in laboratory automation and semi-automated screening workflows a plus
- Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
About Flagship Pioneering:
Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.