Senior Scientist, Antibody Drug Discovery

Workforce Genetics is currently seeking a Senior Scientist to work on antibody drug discovery programs. This position provides the opportunity to join a fast-growing company, provide career advancement opportunities, and provide an atmosphere of learning and development while working on a great team.

The Senior Scientist will work on antibody drug discovery programs related to neurological disorders. This position supports early discovery efforts using molecular biology, protein biochemistry, and antibody discovery methods. The candidate will use a variety of cellular, molecular biology, and biochemical methods in support of drug discovery programs.

Key responsibilities:

• Conduct research in neurological disorders to support drug discovery programs.
• Discover antibody hit molecules using phage/yeast display and/or hybridoma technologies.
• Engineer and optimize antibody lead molecules through sub-library, humanization, and affinity tuning.
• Generate expression constructs and express/purify biologics using a mammalian expression system.
• Characterize antibody properties in various in vitro biochemical and cellular assays.
• Review, analyze, and interpret experimental results and present key findings.
• Analyze data, interpret results, and identify problems.
• Present research findings internally and externally.
• Collaborate with both internal and external scientists in a variety of teams including CROs, translational medicine, medical sciences, and CMC.
• May supervise research associates and scientists.

Skills and Experience:

• Ph.D. in biochemistry, cell and molecular biology, pharmacology, immunology, neurobiology or related field with 4-8 years of relevant experience (including postdoctoral, fellowship training experience) or Master's degree with 10+ years; or Bachelor's degree with 15+ years of experience
• Experience with gene cloning, phage/yeast display, or hybridoma fusion and screening.
• Experience with biochemical assays and quantitative analysis of protein-protein binding interactions such as FACS, ELISA, and Octet.
• Experience with mammalian cell culture, antibody expression and purification, and cell-based assays including cell surface binding (FACS) and functional assays (e.g. signaling/reporter assays, killing assays).
• SPR binding assays (Octet) to measure KD, binding kinetics, and epitope binning eta.
• Familiar with various biologics modalities including mAb, bispecific, and nanobodies.
• CNS-related training or research experience is preferred.
• Pharma / Biotech experience in the areas of biologics, nucleic acids, and/or small molecules.
• Experience in a biotech start-up environment, including working with external partners.