Senior Scientist, Biology
Apply NowCompany: Mariana Oncology
Location: Watertown, MA 02472
Description:
Description:
We are seeking a Senior Scientist, Biology to support the discovery of peptide ligands to specific cancer drug targets using mRNA display platform.
Illustrative Breadth of Responsibilities:
Design and execute biochemical and cellular experiments to characterize binding activities of radio-peptide ligands to cancer targets. High comfort level working with different kinds of radioemitters is a must.
Support hit-lead optimization efforts by screening compounds in a radiolabeled binding assay using cancer cell lines, as well as intellectually contribute towards the screening cascade strategy design.
Support internal and external mechanistic biology efforts to understand cell signaling impact of targeting specific cell surface proteins in cancer cell lines.
Interpret and analyze data, prepare, and review IND-enabling study reports, communicate findings to project teams, stakeholders, and external collaborators.
Requirements/Skills:
Master's degree in Biology, Cell or Molecular Biology, Biotechnology, or a closely related scientific field.
5 years of drug discovery research experience within the biotech or pharmaceutical industries, including:
o 2 years of experience with mRNA display and in vitro translation of unnatural amino acids;
o 5 years of cell-based assay development using techniques including Flow cytometry (MACSQuant platform), live-cell imaging using Incuctye platform, protein quantification/characterization by western blot and ELISA;
o 2 years of experience handling multiple types of radioisotopes to support in vitro assay development; and
o 3 years of IND enabling/post-IND experience.
We are seeking a Senior Scientist, Biology to support the discovery of peptide ligands to specific cancer drug targets using mRNA display platform.
Illustrative Breadth of Responsibilities:
Design and execute biochemical and cellular experiments to characterize binding activities of radio-peptide ligands to cancer targets. High comfort level working with different kinds of radioemitters is a must.
Support hit-lead optimization efforts by screening compounds in a radiolabeled binding assay using cancer cell lines, as well as intellectually contribute towards the screening cascade strategy design.
Support internal and external mechanistic biology efforts to understand cell signaling impact of targeting specific cell surface proteins in cancer cell lines.
Interpret and analyze data, prepare, and review IND-enabling study reports, communicate findings to project teams, stakeholders, and external collaborators.
Requirements/Skills:
Master's degree in Biology, Cell or Molecular Biology, Biotechnology, or a closely related scientific field.
5 years of drug discovery research experience within the biotech or pharmaceutical industries, including:
o 2 years of experience with mRNA display and in vitro translation of unnatural amino acids;
o 5 years of cell-based assay development using techniques including Flow cytometry (MACSQuant platform), live-cell imaging using Incuctye platform, protein quantification/characterization by western blot and ELISA;
o 2 years of experience handling multiple types of radioisotopes to support in vitro assay development; and
o 3 years of IND enabling/post-IND experience.