Senior/Principal Scientist, Biophysics

About Treeline

Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life-threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, lead discovery, medicinal chemistry, and computation to reduce the time and risks of drug discovery.

About the Role

We are seeking an experienced, enthusiastic, and highly motivated Biophysicist to join our San Diego team to deliver high-quality results and drive small molecule drug discovery. The successful candidate will have a critical role in supporting Treeline's drug discovery programs by collaborating closely with the multi-disciplinary Lead Discovery organization across biophysics, biochemistry, structural biology, and protein production, as well as the broader organization including biology, computational chemistry, and medicinal chemistry. Specifically, you will propose, design, and implement new biophysical assays (ie. SPR, MST, DSF, NMR) to characterize protein-small molecule and protein-protein interactions. In addition, the ideal candidate will provide expert interpretation of biophysical and/or biochemical results and use data analysis and visualization tools to integrate data with the broader set of data generated at Treeline to drive program decisions.

Responsibilities

• In collaboration with cross-functional project teams, propose, design, and implement biophysical or biochemical assays/experiments for compound interaction analysis in support of hit ID, hit to lead, and lead optimization activities.
• Efficiently utilize a suite of biophysical techniques to advance drug discovery: primarily SPR but also including DSF, MS, DLS, and MST.
• Employ biophysical methods to mechanistically deconvolute the molecular mechanism of action of small molecule hits.
• Effectively analyze, interpret, and communicate biophysical data as a subject matter expert and biophysics representative on project teams.
• In collaboration with chemistry, biology, lead discovery, and medicine design, characterize and establish SAR to rapidly drive the hit-to-lead process.
• Propose and evaluate new approaches and technologies.
• Provide biophysics leadership to project teams.

Required Qualifications

• PhD in Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 2-3 years of relevant postdoctoral training.
• 5+ years of experience in biotech/pharma industry with a track record of hit-finding, hit-to-lead, and lead optimization to delivering small molecule development candidates.
• Previous experience in small molecule drug discovery, specifically biophysical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
• Strong knowledge of biophysical methods and theory with proven hands-on expertise applying biophysics for interaction analysis. Expertise with application of SPR for small drug discovery. Expertise with MST, DSF, MS, or NMR are a plus.
• Experience with integrated application of a broad array of biophysical or biochemical methods for drug discovery is a plus.
• Attention to detail and good troubleshooting and problem-solving skills.
• Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.

Preferred Qualifications

• Ability to lead in a matrix environment, and for example, act as point of contact on behalf of Lead Discovery within the broader project team
• Experience with fragment-based lead discovery, covalent lead discovery, and DEL are a plus.
• Strong hands-on biochemistry experience or expertise in enzymology.
• Working knowledge of adjacent disciplines (biochemistry, structural biology, protein purification, biology, chemistry).
• Experience in working with challenging proteins.
• Experience working with CROs.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in San Diego is $141,855 to $181,278. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.