Sr Scientist, Bioprocess Development
Apply NowCompany: Denali Therapeutics
Location: South San Francisco, CA 94080
Description:
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This position is responsible for developing efficient, robust and scalable purification processes to support our large molecule pipeline.
Key Accountabilities/Core Job Responsibilities:
Qualifications/Skills:
Salary Range: $142,000.00 to $174,333.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This position is responsible for developing efficient, robust and scalable purification processes to support our large molecule pipeline.
Key Accountabilities/Core Job Responsibilities:
- Design and execute lab-scale chromatography and filtration studies to inform and support large scale process decisions
- Establish a workflow to provide purification support for cell line and cell culture development activities
- Develop methods for in-process testing using ELISA, HPLC, UV and SDS-Page based analytics
- Transfer purification processes to CMOs and support ongoing manufacturing activities as needed
- Author process descriptions, development reports, tech transfer documents and relevant IND sections
- Work closely with discovery groups and project teams to transfer process/molecule knowledge into development
Qualifications/Skills:
- PhD in Biology, Biochemistry, Chemical Engineering or related scientific discipline plus a minimum of 5 years purification development experience in the biotech/biopharma industry; or BS with 10+ years of experience or MS with 8+ years of experience
- Experience developing purification processes to support early and late stage clinical production
- Proven track record of representing bioprocess functions in cross-functional teams and working effectively with CMOs
- Knowledge of process virology, including working with contract labs to plan and execute viral clearance studies is desired
- Broad experience in protein characterization, design of experiments and analytics
- Expertise in AKTA protein purification systems and antibody characterization methods including: HPLC, LC/MS, SDS-PAGE, DLS and other biophysical techniques
- Excellent critical thinking, scientific problem-solving and communication skills
Salary Range: $142,000.00 to $174,333.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.