Structural Biologist (R5-R7)
Apply NowCompany: Eli Lilly
Location: San Diego, CA 92154
Description:
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Eli Lilly and Company seeks a Structural Biologist (R5-R7) to support structure-based drug discovery (SBDD)projects focused on G protein-coupled receptors (GPCRs). Perform structure determination and drug design for GPCR and membrane protein targets as well as soluble protein targets. Apply biochemical, biophysical, and computational techniques to accelerate generation of high-quality reagents for X-ray crystallography and cryogenic electron microscopy (cryo-EM) studies. Determine structures and co-complex structures of protein targets for the design of small-molecule and antibody therapeutics. Develop integrative approaches to SBDD incorporating data and input from structural biology, biophysics, protein biochemistry, and medicinal chemistry teams. #LI-DNI
Position requires a Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field, and 2 years of academic or employment experience with GPCR biology, pharmacology, and structure-based research studies of GPCRs. Academic or employment experience must include a minimum of: 2 years of experience with protein engineering, protein biochemistry, and protein structure determination by X-ray crystallography or cryo-EM; 2 years of experience with construct design, molecular cloning, and protein expression and purification; 2 years of experience with chromatographic methods for isolating recombinant proteins and HPLC/FPLC systems; 2 years of experience with SDS-PAGE, Western blot, thermal shift assays, and ELISA; and 2 years of experience with computational tools for protein structure determination and analysis, including CCP4, Phenix, COOT, PyMol, and Chimera. Part time telecommuting may be permitted. Up to 10% domestic and international travel required. #LI-DNI
Job location: San Diego, CA. RATE OF PAY: $168,709.00 - $178,709.00 per year. To apply, please visit https://jobsearch.lilly.com/ and enter job requisition number R-84158 when prompted. Alternatively, please send your resume, cover letter, and a copy of the ad to: Beth L. Berry, Lilly Corporate Center, Indianapolis, IN 46285.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$133,500 - $232,100
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
Eli Lilly and Company seeks a Structural Biologist (R5-R7) to support structure-based drug discovery (SBDD)projects focused on G protein-coupled receptors (GPCRs). Perform structure determination and drug design for GPCR and membrane protein targets as well as soluble protein targets. Apply biochemical, biophysical, and computational techniques to accelerate generation of high-quality reagents for X-ray crystallography and cryogenic electron microscopy (cryo-EM) studies. Determine structures and co-complex structures of protein targets for the design of small-molecule and antibody therapeutics. Develop integrative approaches to SBDD incorporating data and input from structural biology, biophysics, protein biochemistry, and medicinal chemistry teams. #LI-DNI
Position requires a Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field, and 2 years of academic or employment experience with GPCR biology, pharmacology, and structure-based research studies of GPCRs. Academic or employment experience must include a minimum of: 2 years of experience with protein engineering, protein biochemistry, and protein structure determination by X-ray crystallography or cryo-EM; 2 years of experience with construct design, molecular cloning, and protein expression and purification; 2 years of experience with chromatographic methods for isolating recombinant proteins and HPLC/FPLC systems; 2 years of experience with SDS-PAGE, Western blot, thermal shift assays, and ELISA; and 2 years of experience with computational tools for protein structure determination and analysis, including CCP4, Phenix, COOT, PyMol, and Chimera. Part time telecommuting may be permitted. Up to 10% domestic and international travel required. #LI-DNI
Job location: San Diego, CA. RATE OF PAY: $168,709.00 - $178,709.00 per year. To apply, please visit https://jobsearch.lilly.com/ and enter job requisition number R-84158 when prompted. Alternatively, please send your resume, cover letter, and a copy of the ad to: Beth L. Berry, Lilly Corporate Center, Indianapolis, IN 46285.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$133,500 - $232,100
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly