Senior Research Investigator - Biochem & Molecular Biology

The Pomerantz lab seeks a Senior Research Investogator to conduct cryo-electron microscopy (cryo-EM) structure biology, X-ray crystallography, and biochemical research on DNA repair proteins involved in cancer proliferation. The position requires a PhD, a minimum of 4 years of experience in cryo-electron microscopy and X-ray crystallography methods and solving high-resolution cryo-EM and X-ray structures, a minumum of 5 years of experience in protein biochemistry and molecular biology, and at least 3 years of experience in training junior scientists. The preferred candidate will have expertise in the structure biology of nucleic-acid enzymes.

The research associate will carry out structure biology and biochemical experiments as part of a team of bio-medical researchers to develop small-molecule inhibitors of DNA repair proteins involved in cancer proliferation. The research associate will be required to independently design experimental procedures and interpret results, form hypotheses, and train and mentor research personnel and graduate students on cryo-electron microscopy techniques and other structure biology techniques.The research associate will record and analyze experimental results and collaborate effectively with other team members. Other responsibilities include help maintaining databases of technical methods and protocols, plasmids, and other key resources, maintain accurate records, troubleshoot experimental design malfunctions and implement solutions .

The Senior Research Investigator (SRI) will be a high-level leadership role in the laboratory, acting as key overseer of all fundamental activities associated with the conduct of sponsored science in an academic environment, and support multiple research projects in a collaborative setting. The SRI will execute key projects and help lead the scientific management of other personnel in the laboratory. The SRI will determine job complexity, set priorities and supervise the day-to-day experimental techniques related to conducting standardized procedures and experiments.

Essential Functions:

• Interacts with co-workers, visitors, and other staff consistent with the values of Jefferson.

• Develops strategic plan to define multiple project objectives and execute the mission of the project team and experiment timelines.

• Designs and implements experiments. Carryout complex laboratory experiments or delegate procedures to laboratory staff.

• Trains and supervises laboratory staff in technical procedures, processes and methods, data observation, documentation and management via electronic lab notebooks. Assures laboratory members are properly trained in the use of research equipment and standard operating procedures (SOP) in the laboratory including Biosafety compliance. Identifies, recommends and implements changes to enhance rigor and reproducibility

• Monitors progress of research and data. Ensures high-quality results are achieved in a timely and organized manner. Ensures all research is undertaken in accordance with current University, state and federal regulations.

• Independently prepares oral and written reports. Coherently and effectively communicates research findings in the form of posters, presentations for PI at local and national meetings, abstracts and manuscripts, as well as the basis for grant writing, preparation and submission with PI as appropriate. Generates publication quality figures for grants and manuscripts. Writes and edits experimental and technical sections of grant applications.

Qualifications

Minimum Education and Experience Requirements:

Education:

MD or Ph.D.in Biology, Biomedical Sciences or related field required.

AND

Experience:

5 plus years of lab management experience required.

Conditions of Employment

Covid Vaccination is a requirement for employment at Jefferson for employees working at Jefferson's clinical entities or at the University. If you are not currently vaccinated you will be required to receive the vaccination prior to hire date if you are offered employment, unless you request and receive an approved medical or religious exemption from Jefferson.

Closing Statement

Jefferson includes Thomas Jefferson University and Jefferson Health, a dynamic university and health system with broad reach across the Delaware Valley. Jefferson is the second largest employer in Philadelphia and the largest health system in Philadelphia based on total licensed beds.

Through the merger of Thomas Jefferson University and Philadelphia University in 2017, our University includes ten colleges and four schools. We are an NCAA Division II university and an R2 national doctoral university offering undergraduate and graduate-level programs that provide students with a forward-thinking education in architecture, business, design, engineering, fashion and textiles, health, medicine and social science.

Jefferson Health, the clinical arm of Thomas Jefferson University, has grown from a three-hospital academic health center in 2015, to an 18-hospital health system through mergers and combinations that include hospitals at Abington Health, Aria Health, Kennedy Health, Magee Rehabilitation and Einstein Healthcare Network. We have over 50 outpatient and urgent care centers; ten Magnet-designated hospitals (recognized by the ANCC for nursing excellence); the NCI-designated Sidney Kimmel Cancer Center (one of only 70 in the country and one of only two in the region); and one of the largest faculty-based telehealth networks in the country. In 2021, Jefferson Health became the sole owner of HealthPartners Plan, a not-for-profit health maintenance organization in Southeastern Pennsylvania. We are the first health system regionally to create an aligned payer-provider partnership.

Jefferson's mission, vision and values create an organization that attracts the best and the brightest students, faculty, staff, and healthcare professionals, as well as the most visionary leaders to drive exceptional results.

• OUR MISSION: We improve lives.
• OUR VISION: Reimagining health, education and discovery to create unparalleled value
• OUR VALUES: Put People First, Be Bold & Think Differently and Do the Right Thing

As an employer, Jefferson maintains a commitment to provide equal access to employment. Jefferson values diversity and encourages applications from women, members of minority groups, LGBTQ individuals, disabled individuals, and veterans.