Principal Scientist - Analytical Development

About Apogee Therapeutics

Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally.

Apogee Therapeutics, Inc. is a biotechnology company seeking to develop differentiated biologics for the treatment of atopic dermatitis, chronic obstructive pulmonary disease and other inflammatory and immunology indications with high unmet need. Our antibody programs are designed to potentially overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. We seek to reshape the current standard of care for inflammatory and immune diseases because we believe people living with these diseases deserve the best possible treatment, and we refuse to stop at "good enough."

We are a fast-paced company committed to building an exceptional company culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless.

If this sounds like you, keep reading!

Role Summary

We are seeking a Principal Scientist, Analytical Development. This newly created position is a highly collaborative leadership and technical position based in our Research and Development lab in Boston. You will manage technical and operational aspects of Analytical Development activities in the lab supporting Apogee's monoclonal antibody pipeline. These activities include non-GMP analytical characterization, method development, and R&D sample testing. In this role you will be an important member of the Tech Ops team, managing multiple activities in parallel at various stages of drug development.

Key Responsibilities

• Lead and manage a team of laboratory scientists, providing guidance, mentorship, and support to ensure high performance and professional growth.
• Design, develop, and implement analytical methods for the testing and characterization of monoclonal antibody projects, working internally or with contracted partners.
• Design and execute experiments to support upstream/downstream process development, formulation studies, product characterization and comparability studies.
• Oversee the daily operations of the analytical development laboratory, ensuring compliance with safety, quality, and regulatory requirements.
• Collaborate with cross-functional teams, including process development and R&D, to support project goals and timelines.
• Analyze and interpret complex data sets, providing clear and actionable insights and recommendations.
• Prepare technical reports, presentations, and documentation to communicate findings and progress to stakeholders.
• Stay current with industry trends, advancements to continuously improve laboratory practices and methodologies.

Ideal Candidate

• PhD in Analytical Chemistry, Biochemistry, or related field, with a minimum of 7 years of relevant industry experience in an analytical development role.
• Proven experience in leading and managing a team of scientists in a laboratory setting,
• Large molecule and protein characterization experience is required.
• Extensive knowledge in several analytical techniques such as H/UPLC (SEC, RP, HILIC, IEX), electrophoresis (CE-SDS, icIEF), spectrophotometry, ELISAs, and cell-based bioassays.
• Strong problem-solving skills and the ability to design and conduct complex experiments.
• Experience in Empower, Chemstation, Softmax software is desired.
• Excellent communication skills with an ability to collaborate effectively across functional lines.
• Strong organizational and project management skills, with the ability to manage multiple projects simultaneously.
• Familiarity with regulatory requirements and guidelines (e.g., FDA, ICH) related to analytical development.
• Successfully exhibit Apogee's C.O.R.E. values: Caring, Original, Resilient and Egoless
• Ability and willingness to travel up to eight times a year for company-wide meetings as well as Tech Ops team meetings.
• This on-site position requires a minimum of 4 days per week on site at our lab in Boston (Seaport area)

The anticipated salary range for candidates for this role will be $185,000-$200,000/year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.

What We Offer

• A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless
• Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
• Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
• Flexible PTO
• Two, one-week company-wide shutdowns each year
• Commitment to growing you professionally and providing access to resources to further your development
• Apogee offers regular all team, in-person meetings to build relationships and problem solve

E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster.

Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

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