Director/Sr. Director, In Vivo Pharmacology

When our people share why they join Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we're driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we're doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder.

The strength of Rapport comes from our Rapptors - who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you're as excited about this opportunity as we are!

Your day-to-day:

• Develop and execute forward-looking discovery strategies that support the company's pipeline, ensuring that in vivo studies are both innovative and aligned with overall goals
• In collaboration with DMPK contribute to the design, direction, execution, and analysis of pharmacological studies to advance candidates by supporting pharmacokinetic/pharmacodynamic (PK/PD) analysis, disease modeling and mechanism of action studies to support human dose projections.
• Provide strong leadership and guidance to the in vivo sciences team, fostering a collaborative and high-performing research environment.
• Stay up to date with the latest developments regarding in vivo research methods, technologies, and industry trends while adopting innovative strategies that elevate the quality and effectiveness of in vivo studies.
• Put in place a network of external subject matter experts and contract research organizations to assist with development of animal models and translational studies
• Demonstrate a high level of initiative to troubleshoot and accurately perform data analysis on in vivo studies. Proactively investigate, improve, change, or adapt existing methods and techniques.
• Partner with Translational medicine to identify and develop preclinical and clinical biomarkers to implement in in vivo pharmacology studies
• Work closely with biology, medicinal chemistry, DMPK and clinical teams as a project team member and functional area lead to support lead optimization and candidate selection
• Collaborate with biology program leads to identify relevant in vivo models
• Provide scientific insights to support decision making through robust analysis and interpretation of data such that meaningful conclusions can be drawn
• Author scientific publications and write in vivo pharmacology reports to support regulatory filings.
• Ensure effective communication and collaboration across internal teams and with external stakeholders to ensure a unified approach to achieving research objectives

Must-Haves:

• PhD in Pharmacology, Neuroscience, Biological Sciences or a related life sciences field
• 15+ years of hands-on experience in designing and leading in vivo pharmacology studies in neuroscience, with a minimum of 10 years in leadership roles.
• Experience in small molecule research and a strong background in neuroscience are required
• Extensive experience in the design and execution of in vivo studies, aimed at establishing IVIVC and PK/PD relationships is required
• Proven leadership abilities, demonstrated through experience in building, guiding, and developing high-performing scientific teams
• Extensive knowledge of animal care, use and regulatory guidelines (IACUC) is required
• A strategic thinker with the ability to analyze possibilities, evaluate benefit/ risks and think of mitigation approaches and solutions
• Strong communication skills, with the ability to effectively collaborate with cross-functional teams and external partners.

What makes working here great:

• Every role has meaning. We're determined to discover a better way for patients, and you'll feel the passion from the start.
• We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
• Your perspective matters. Stick your neck out, share your ideas - we work as a team.
• We have FUN. We hire smart, dedicated, down-to-earth people that you'll enjoy spending time with.
• Leadership that CARES - about you, your growth + development.
• We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston - we make the most of our time together.
• Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
• You get to be YOU! Show up as you are and make every day count.

Your Compensation

We get it. Compensation is an important part of your offer. You shouldn't be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for this role to be $200,000 to $275,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don't stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.

The anticipated salary range for candidates who will work in San Diego CA is listed below. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, education, etc. Rapport Therapeutics, is a multi-state employer and this salary range may not reflect positions that work only in other states.

California Salary Range

$200,000-$275,000 USD

Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

CCPA disclosure notice can be found here.