Immunology Team Research Scientist/Engineer 3
Apply NowCompany: University of Washington
Location: Seattle, WA 98115
Description:
As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem-solving skills, and dedication to build stronger minds and a healthier world.
UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits, and natural beauty.
The Tumor Immune Micro-environment (TIME) lab in the Department of Surgery is seeking a Research Scientist/Engineer (RSE) 3 to join this lab. The Department of Surgery is part of UW School of Medicine.
The TIME lab is a highly interactive group of basic scientists and surgeon-scientists who address issues related to cancer and the immune system. We are linked to the vibrant Seattle immunology research community through the Department of Immunology, the Benaroya Institute, and the Fred Hutch Cancer Research Institute.
POSITION PURPOSE
The goal of the UW TIME Lab is to develop a precise understanding of the nature of the adaptive immune response to solid tumors in order to develop effective immunotherapies. While much of our work focuses on pancreatic and colorectal carcinoma, we are particularly interested in shedding light on aspects of tumor biology that reach across many tumor types. Our central goal is to address how the immunosuppressive microenvironment created by solid tumors can be altered to enable reactivation of endogenous T-cell responses. In concert with this work, we are also finding that adoptively transferred T-cells (e.g. CAR-T cells) are subject to similar mechanisms of immunosuppression in the TIME.
As an integral member of the team, the Research Scientist/Engineer will perform hands-on research in small animal immunology, including mouse genetics and animal handling. The RSE will be responsible for typing, microscopy, flow cytometry, immune cell isolation and tests of immune function.
DUTIES AND RESPONSIBILITIES
Under general direction, the RSE will work to identify research problems and perform research using double-transgenic experimental animals in which fluorescent lineage-tracing reporters identify specific cell types in the cancer stroma; cell and organ harvest, cell isolation using tissue homogenization and flow cytometric cell sorting, cell culture and the measurement of cytokines.
The Research Scientist Engineer's major duties are:
Conduct of hands-on research in the TIME Lab = 85%
Research animal immunology using small animals (mice). Responsibilities include:
oPerform mouse genetics and typing, using double-transgenic experimental animals in which fluorescent lineage-tracing reporters Identify specific cell types in the cancer stroma
oPerform cell and organ harvesting
oPerform immune cell isolation using tissue homogenization and flow cytometry, microscopy and tests immune function
oPerform cell sorting, cell culture and measurement of cytokines
oWork to create technological methodology by expanding existing or developing new approaches
oMonitor the work of more junior staff to ensure procedures are followed; perform collaborative work within the team and accomplish organizational goals
Data analysis contributes to research manuscripts, team communication and collaboration = 15%
oEnsure accurate data input and participate in analysis of data
oContribute data for reports and publications
oEffectively contribute to team cohesion and collaboration
oAssist in finding additional/new funding through contributions to technical grant proposals
oMake presentations on research as required
This is a 1.0 FTE position and the RSE 3 will have a dual reporting relationship: They will report to Dr. Crispe, Professor and group leader, for all research activity. For administrative purposes, the RSE 3 will report to the Administrator of the Division of General Surgery in the Department of Surgery, School of Medicine.
Our Mission and How This Position Contributes:
Research is one of the three pillars of academic medicine. Bringing together scientists from multiple departments and research institutes allows for collaborative basic and translational research in the area of immunology which has the possibility of significantly changing treatment of cancer. This position will have a pivotal spot on this team.
Department Mission:
The Department of Surgery is a large department within the School of Medicine, with surgeons practicing at all our locations and in eight surgical subspecialties. The UW Department of Surgery is guided by our mission of providing compassionate and high-quality patient care, training future generations of surgical leaders, and conducting research in a collegial environment that embraces diversity and promotes inclusiveness.
Our Commitment to Equity, Diversity, and Inclusion (EDI):
The Department of Surgery strives to dismantle systemic racism, eliminate healthcare disparities, and promote health equity in our work. Racism and intolerance have no place in our community. We celebrate our multitude of intersecting identities and commit to the ongoing effort of creating an inclusive and supportive workplace climate.
All staff in the Department of Surgery are asked to demonstrate and develop the following core competencies:
Quality Focus: strives to deliver the best possible service and results, and continuously seeks opportunities for improvement.
Key attributes: accuracy, customer service, continuous improvement, problem solving, and self-development
Planning & Organization: completes work in a timely, efficient, and resourceful manner
Key attributes: priority setting, efficiency, resourcefulness, adaptability and flexibility, organizational awareness, and initiative
Teamwork & Relationship Building: builds and fosters positive working relationships with others to achieve shared objectives.
Key attributes: collaboration, communication, emotional intelligence, recognition, and accountability, and integrity
Equity, Diversity, and Inclusion: values and honors diverse experiences and perspectives, strives to create welcoming and respectful work environments including dismantling structures of oppression, promotes and contributes to a culture of access, opportunity, and justice.
Key attributes: respect, cultural humility, inclusiveness, advocacy, and commitment
MINIMUM REQUIREMENTS
Minimum Education/Experience:
Bachelor's degree in Biologic sciences or a related field and four years of relevant experience OR equivalent combination of education/experience.
ADDITIONAL REQUIREMENTS
Experience in research using small animals
Experience with organ harvesting, cell isolation, cell culture and sorting
Experience measuring cytokines
Able to isolate DNA, RNA, and perform PCR, RT-PCR and qPCR
Experience with gel electrophoresis
Data analysis experience
Preparation and drafting publications
DESIRED QUALIFICATIONS
Master's or PhD in Biologic sciences or other relevant - Strongly preferred.
5 Years of experience as a professional researcher in the area of immunology.
Conditions of Employment:
This is an essential position due to laboratory animal care and maintenance.
On-site with only occasional remote work possibility.
Equivalent education/experience can substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration. Candidates of non-traditional educational or experiential backgrounds are invited to apply. Please address the applicability of education and experience in your resume.
Equity, Diversity, and Inclusion Statement:
In addition, as a part of our hiring process, during any initial screening that may occur for you as a candidate, you will be asked to provide a statement demonstrating your experience with or commitment to Equity, Diversity & Inclusion (EDI). The following may be used as a guide in helping you to prepare your statement:
Define what your values are as they relate to your understanding of the terms Equity, Diversity & Inclusion.
Describe your past and/or present experience with EDI (workplace, volunteer, or other experience of significance).
What EDI implementations or efforts would help create a healthy and safe work environment for you?
How would you contribute to promoting EDI efforts/initiatives in the workplace?
Please make your statement limited to 300-400 words.
Application Process: The application process may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are access ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.
To request disability accommodation in the application process, contact the Disability Services Office at [redacted] or [redacted].
Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.
UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits, and natural beauty.
The Tumor Immune Micro-environment (TIME) lab in the Department of Surgery is seeking a Research Scientist/Engineer (RSE) 3 to join this lab. The Department of Surgery is part of UW School of Medicine.
The TIME lab is a highly interactive group of basic scientists and surgeon-scientists who address issues related to cancer and the immune system. We are linked to the vibrant Seattle immunology research community through the Department of Immunology, the Benaroya Institute, and the Fred Hutch Cancer Research Institute.
POSITION PURPOSE
The goal of the UW TIME Lab is to develop a precise understanding of the nature of the adaptive immune response to solid tumors in order to develop effective immunotherapies. While much of our work focuses on pancreatic and colorectal carcinoma, we are particularly interested in shedding light on aspects of tumor biology that reach across many tumor types. Our central goal is to address how the immunosuppressive microenvironment created by solid tumors can be altered to enable reactivation of endogenous T-cell responses. In concert with this work, we are also finding that adoptively transferred T-cells (e.g. CAR-T cells) are subject to similar mechanisms of immunosuppression in the TIME.
As an integral member of the team, the Research Scientist/Engineer will perform hands-on research in small animal immunology, including mouse genetics and animal handling. The RSE will be responsible for typing, microscopy, flow cytometry, immune cell isolation and tests of immune function.
DUTIES AND RESPONSIBILITIES
Under general direction, the RSE will work to identify research problems and perform research using double-transgenic experimental animals in which fluorescent lineage-tracing reporters identify specific cell types in the cancer stroma; cell and organ harvest, cell isolation using tissue homogenization and flow cytometric cell sorting, cell culture and the measurement of cytokines.
The Research Scientist Engineer's major duties are:
Conduct of hands-on research in the TIME Lab = 85%
Research animal immunology using small animals (mice). Responsibilities include:
oPerform mouse genetics and typing, using double-transgenic experimental animals in which fluorescent lineage-tracing reporters Identify specific cell types in the cancer stroma
oPerform cell and organ harvesting
oPerform immune cell isolation using tissue homogenization and flow cytometry, microscopy and tests immune function
oPerform cell sorting, cell culture and measurement of cytokines
oWork to create technological methodology by expanding existing or developing new approaches
oMonitor the work of more junior staff to ensure procedures are followed; perform collaborative work within the team and accomplish organizational goals
Data analysis contributes to research manuscripts, team communication and collaboration = 15%
oEnsure accurate data input and participate in analysis of data
oContribute data for reports and publications
oEffectively contribute to team cohesion and collaboration
oAssist in finding additional/new funding through contributions to technical grant proposals
oMake presentations on research as required
This is a 1.0 FTE position and the RSE 3 will have a dual reporting relationship: They will report to Dr. Crispe, Professor and group leader, for all research activity. For administrative purposes, the RSE 3 will report to the Administrator of the Division of General Surgery in the Department of Surgery, School of Medicine.
Our Mission and How This Position Contributes:
Research is one of the three pillars of academic medicine. Bringing together scientists from multiple departments and research institutes allows for collaborative basic and translational research in the area of immunology which has the possibility of significantly changing treatment of cancer. This position will have a pivotal spot on this team.
Department Mission:
The Department of Surgery is a large department within the School of Medicine, with surgeons practicing at all our locations and in eight surgical subspecialties. The UW Department of Surgery is guided by our mission of providing compassionate and high-quality patient care, training future generations of surgical leaders, and conducting research in a collegial environment that embraces diversity and promotes inclusiveness.
Our Commitment to Equity, Diversity, and Inclusion (EDI):
The Department of Surgery strives to dismantle systemic racism, eliminate healthcare disparities, and promote health equity in our work. Racism and intolerance have no place in our community. We celebrate our multitude of intersecting identities and commit to the ongoing effort of creating an inclusive and supportive workplace climate.
All staff in the Department of Surgery are asked to demonstrate and develop the following core competencies:
Quality Focus: strives to deliver the best possible service and results, and continuously seeks opportunities for improvement.
Key attributes: accuracy, customer service, continuous improvement, problem solving, and self-development
Planning & Organization: completes work in a timely, efficient, and resourceful manner
Key attributes: priority setting, efficiency, resourcefulness, adaptability and flexibility, organizational awareness, and initiative
Teamwork & Relationship Building: builds and fosters positive working relationships with others to achieve shared objectives.
Key attributes: collaboration, communication, emotional intelligence, recognition, and accountability, and integrity
Equity, Diversity, and Inclusion: values and honors diverse experiences and perspectives, strives to create welcoming and respectful work environments including dismantling structures of oppression, promotes and contributes to a culture of access, opportunity, and justice.
Key attributes: respect, cultural humility, inclusiveness, advocacy, and commitment
MINIMUM REQUIREMENTS
Minimum Education/Experience:
Bachelor's degree in Biologic sciences or a related field and four years of relevant experience OR equivalent combination of education/experience.
ADDITIONAL REQUIREMENTS
Experience in research using small animals
Experience with organ harvesting, cell isolation, cell culture and sorting
Experience measuring cytokines
Able to isolate DNA, RNA, and perform PCR, RT-PCR and qPCR
Experience with gel electrophoresis
Data analysis experience
Preparation and drafting publications
DESIRED QUALIFICATIONS
Master's or PhD in Biologic sciences or other relevant - Strongly preferred.
5 Years of experience as a professional researcher in the area of immunology.
Conditions of Employment:
This is an essential position due to laboratory animal care and maintenance.
On-site with only occasional remote work possibility.
Equivalent education/experience can substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration. Candidates of non-traditional educational or experiential backgrounds are invited to apply. Please address the applicability of education and experience in your resume.
Equity, Diversity, and Inclusion Statement:
In addition, as a part of our hiring process, during any initial screening that may occur for you as a candidate, you will be asked to provide a statement demonstrating your experience with or commitment to Equity, Diversity & Inclusion (EDI). The following may be used as a guide in helping you to prepare your statement:
Define what your values are as they relate to your understanding of the terms Equity, Diversity & Inclusion.
Describe your past and/or present experience with EDI (workplace, volunteer, or other experience of significance).
What EDI implementations or efforts would help create a healthy and safe work environment for you?
How would you contribute to promoting EDI efforts/initiatives in the workplace?
Please make your statement limited to 300-400 words.
Application Process: The application process may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are access ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.
To request disability accommodation in the application process, contact the Disability Services Office at [redacted] or [redacted].
Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.