Scientist / Sr. Scientist, Protein Sciences

Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics.Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Manifold Bio is seeking an enthusiastic, creative scientist to join our growing team in our mission of multiplexed, in vivo drug discovery. The ideal candidate will have extensive experience in protein production focused on the generation of therapeutic constructs. This is a unique opportunity to own impactful projects and play an integral role on a small team looking to redefine current drug discovery paradigms. You will be an essential part in every step of our protein therapeutics work, from designing expression vectors to high-throughput cloning and large-scale expressions, optimization of purification processes, full characterization suites, and formulation for in-vivo studies performed using candidates for clinical development. In particular, you will focus on iterating in the realms of both protein production and utilization of the unique protein multiplexing technology we've developed at Manifold.

You will work closely with a collaborative, interdisciplinary team of scientists to design, execute, and analyze complex experiments in a fast-paced environment. There will be many opportunities for creativity, innovation, and ownership in this hands-on role leveraging our cutting edge platform to initiate and advance programs. Together, we'll continue to build a transformational company based on the original vision of massively increasing the throughput of testing of protein therapeutic designs to fundamentally change the current paradigm of drug development.

Responsibilities

• Independently design, plan and execute experiments to advance drug candidates and programs
• Work collaboratively with the Protein Sciences team to generate protein constructs bound for in-vivo studies
• Build on current expression, purification, and characterization methods to increase throughput and efficiency
• Balance ownership of long-term innovation projects with construct production to advance pipelines
• Contribute to lead validation experiments and prepare preclinical data packages
• Stay up to speed on cutting edge research and industry standards for protein therapeutics
• Maintain data integrity and effectively communicate findings to the team

Required Qualifications

• PhD in protein biochemistry, molecular biology, cell biology, bioengineering or similar; or B.S./M.S. with at least 5 years experience
• Experience in molecular cloning techniques such as Gibson/Golden Gate assembly, restriction digests, etc.
• Expertise in protein biochemistry, especially purification and characterization techniques
• Hands on experience in binder-based protein analysis and in-vivo construct formulation
• Experience troubleshooting difficult scientific problems
• Collaborative, curious, and flexible, with a genuine passion for innovative science and developing medicines

Preferred Qualifications

• 3+ years experience in pharma/biotech industry working on protein therapeutic drug program(s)
• Experience in protein engineering in the context of antibody constructs, single-domain antibodies, or similar
• Understanding of ELN practices related to metadata registration and molecule tracking through experiments
• Experience designing and running high throughput screening assays
• Knowledge of cell biology and cancer biology is a plus

Why you might be a good fit

• Highly independent, productive, and creative scientist able to confront obstacles to drive projects forward
• Team player with enthusiasm for working closely with a tight-knit team on challenging problems
• Strong oral and written communication to facilitate complex experiments with multiple parties; excellent record keeping
• Forethought, organization, and flexibility to meet deadlines and iterate in a fast-paced environment

If you're excited to build a platform that combines DNA and protein multiplexing technologies, please apply!

Benefits

Highly competitive additional benefits package across healthcare, paid time off, commuter benefits, and company-provided lunch every day.

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.