Director, mRNA Process Development
Apply NowCompany: Beam Therapeutics
Location: Cambridge, MA 02139
Description:
Company Overview
Beam Therapeutics is committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam's suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
Beam Therapeutics is seeking a highly talented Director with deep expertise in mRNA process development, optimization and scale-up. The suitable candidate will have a good understanding of mRNA science with experience in mRNA production, purification, and characterization. The ideal candidate is an inspirational leader with broad experience driving development activities for early and late-stage programs and a firm grasp on Quality by Design principles. This role will be responsible for leading a group of development scientists working on evaluation and process optimization of mRNA production.
Responsibilities:
Qualifications:
Beam Therapeutics is committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam's suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
Beam Therapeutics is seeking a highly talented Director with deep expertise in mRNA process development, optimization and scale-up. The suitable candidate will have a good understanding of mRNA science with experience in mRNA production, purification, and characterization. The ideal candidate is an inspirational leader with broad experience driving development activities for early and late-stage programs and a firm grasp on Quality by Design principles. This role will be responsible for leading a group of development scientists working on evaluation and process optimization of mRNA production.
Responsibilities:
- Accountable for mRNA manufacturing process development, scale-up, and tech transfer
- Lead team of development scientists in evaluation and optimization of mRNA manufacturing processes
- Establish team goals and standards that are consistent with company priorities and objectives
- Define long term mRNA process development objectives and strategies
- Serve as mentor to team - providing career coaching and technical guidance
- Work cross-functionally to identify areas of risk, drive continuous improvement, and champion operational excellence with internal and external partners
- Analyze, interpret, and present data to internal and external audiences using various formats
Qualifications:
- PhD degree and 10 to 12 years' experience or MS degree with 15 years process development experience in a Pharmaceutical or CDMO organization
- Previous experience with mRNA manufacturing process is a must
- Good understanding of cGMP manufacturing guidelines
- Prior experience with tech transfer of mRNA, Oligos, Biologics process highly desirable.
- Knowledge of key analytical testing of oligos and mRNA is desirable
- Proven Leadership
- Good communication skills.
- Strong work ethic