Associate Director of Oligonucleotide Chemistry

Job Title: Associate Director of Oligonucleotide Chemistry

Location: South San Francisco

Company: Evercrisp Biosciences

Company Description:

Evercrisp Biosciences, founded by world-renowned scientists with expertise in cutting-edge proprietary technologies, operates in stealth mode with substantial Series A backing from Apple Tree Partners (ATP). Evercrisp is focused on tackling genetically validated, "difficult-to-drug" targets, particularly in areas of high unmet need where genetic medicines can create transformative outcomes. At Evercrisp, innovation, collaboration, and a deep commitment to advancing human health drive our mission to develop first-in-class therapeutics.

Position Summary:

We are seeking an exceptional and innovative thought leader in oligonucleotide chemistry to join our Chemistry team as we develop cutting-edge oligonucleotide-based drug candidates. In this role, you will lead the design, generation, and characterization of oligonucleotide materials to advance therapeutic drug candidates for rare genetic diseases using our novel tissue-targeting platform. The ideal candidate will excel in a fast-paced, dynamic environment and possess a strong blend of leadership and technical skills.

Key Responsibilities:

• Drive therapeutic programs from early discovery to IND-enabling endpoints.

• Design and implement innovative, chemistry-based solutions for oligonucleotide drug discovery challenges.

• Effectively manage external CROs and internal team to meet project goals on time and within budget. Conduct rigorous data analysis, interpret results, and provide clear, data-driven insights to guide project/program decisions.

• Provide technical leadership to team members performing complex work and achieving diverse objectives.

• Ensure data integrity and accessibility through detailed and accurate record-keeping in Electronic Laboratory Notebooks (ELNs).

• Contribute to intellectual property filings and high-impact scientific publications.

• Collaborate with cross-functional teams to identify bottlenecks, troubleshoot challenges and drive continuous improvement initiatives.

Qualifications:

Ph.D. in Chemistry, Biochemistry or related fields with 5+ years of industry experience.

Technical Experience:

• Expertise in solid-phase oligonucleotide synthesis for short- and long-mers (12-120 bp) with a range of chemical modifications.

• Proven track record in designing and optimizing oligonucleotides (e.g., siRNA, PMOs, ASOs, sgRNA) for therapeutic applications.

• Proven ability in leading drug discovery and development projects in an industry setting.

• Demonstrated success in contributing to advancing therapeutic projects/programs.

• Strong knowledge of analytical techniques for oligonucleotide-based therapeutics.

• Experience managing and collaborating with CRO teams to deliver on aggressive timelines.

• Prior experience in developing therapeutic oligonucleotide delivery systems is preferred.

Skills and Attributes:

• Strong ability to synthesize complex technical and functional knowledge and communicate effectively in written and verbal formats.

• Strategic foresight and judgement in planning, organizing, and guiding projects.

• Strong organizational skills, with meticulous attention to detail and adherence to lab safety and best practices.

• Demonstrated expertise in method development, protocol optimization, and technical documentation.

• Demonstrated ability to manage time and resources effectively across multiple projects in a fast-paced environment.

• Collaborative team player with a growth mindset, thriving in dynamic and innovative environments