Senior Scientist, Biochemistry, Biotherapeutics

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

This position will primarily be at the bench to independently conceive, initiate, and direct protein production and related technology development efforts, in alignment with the goals of the Biotherapeutic Discovery organization and responsible for leading the production of large molecule biotherapeutics from milligram to gram scale, including development of robust and scalable purification processes and fit-for-purpose analytics that support the identification and characterization of novel therapeutics

Key Accountabilities/Core Job Responsibilities:

• Develop and troubleshoot protein expression and purification processes for large molecule biotherapeutics.
• Evaluate and establish technologies to enhance and/or advance protein production and characterization, including high-throughput approaches, in support of Discovery projects, platforms, and pathways.

• Develop and perform protein purification, biophysical and biochemical characterizations. In this capacity, support and meet timelines for production of a wide variety of proteins, including antibodies, enzymes, Fc-fusions, bioconjugated proteins, and protein complexes.
• Analyze proteins using standard methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others).
• Coordinate activities and work collaboratively with colleagues across Discovery and Development to meet timelines and to help advance programs.
• Think creatively about ways to integrate novel protein modalities with Denali's BBB-crossing technologies.
• Actively contribute to project teams and work effectively across functional teams to help advance programs to development.

Qualifications/Skills:

• PhD in Biochemistry or related scientific discipline with >5 years of experience in biotech/biopharma industry; or M.Sc with 8; or or B.Sc. 12 years of relevant experience, respectively.
• Extensive knowledge and hands-on experience in the purification and analytical characterization of challenging proteins, complexes and fusion proteins.
• Demonstrated and documented experience in producing and assessing the purity and activity of complex proteins such as engineered antibodies, Fc-fusions and/or bioconjugated therapeutics.
• Extensive programming experience of automated liquid handlers and/or protein purification platforms (FPLC/HPLC/robotics).
• Excellent oral, presentation and written communication skills are required.
• Ability to work in a highly dynamic and fast paced environment to contribute to multiple projects.
• Self-motivated with excellent record keeping and written and verbal communication skills.
• Creative thinker with a strong sense of responsibility and a desire to collaborate in an exciting and fast-paced research environment.

Salary Range: $129,000.00 to $181,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.