Scientist III, Biology
Apply NowCompany: Fusion Pharmaceuticals US, Inc.
Location: Hamilton, ON L8H 7T6
Description:
Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion's clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.
Responsibilities
The Scientist III, Biology will be expected to lead the scientific execution of drug discovery projects by designing and conducting experiments in the lab, analyzing and interpreting data, and communicating results according to timelines
Identify and develop new techniques and assays to expand or enhance existing programs
Mentor junior scientists assigned to their projects/programs and supervise their work
Design and conduct biologic screening assays, mechanisms of action studies, therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer (or other disease indications of interest)
Produce high quality and well documented data with strong attention to detail
Foster scientific excellence, open scientific exchange, and deep scientific rigor
Present experimental results at both internal and external meetings
Qualifications
Ph.D. in Molecular/Cell Biology, Biology, Biochemistry or related field with 5+ years of post-doctoral experience
Experience in cancer Biology and preclinical drug development
Experience in drug screening and candidate drug selection is an asset
Previous experience in mentoring junior scientists is preferred
Experience with development and technical validation of in vitro bioassays and biologic screening assays
Experience with development and validation of in vivo cancer models in small rodents
Demonstrated ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment
Demonstrated success in generation of actionable data to inform a go/no-decision point within a project/program
Experience with the safe handling of radioactive and biohazardous materials
Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels
Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Responsibilities
The Scientist III, Biology will be expected to lead the scientific execution of drug discovery projects by designing and conducting experiments in the lab, analyzing and interpreting data, and communicating results according to timelines
Identify and develop new techniques and assays to expand or enhance existing programs
Mentor junior scientists assigned to their projects/programs and supervise their work
Design and conduct biologic screening assays, mechanisms of action studies, therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer (or other disease indications of interest)
Produce high quality and well documented data with strong attention to detail
Foster scientific excellence, open scientific exchange, and deep scientific rigor
Present experimental results at both internal and external meetings
Qualifications
Ph.D. in Molecular/Cell Biology, Biology, Biochemistry or related field with 5+ years of post-doctoral experience
Experience in cancer Biology and preclinical drug development
Experience in drug screening and candidate drug selection is an asset
Previous experience in mentoring junior scientists is preferred
Experience with development and technical validation of in vitro bioassays and biologic screening assays
Experience with development and validation of in vivo cancer models in small rodents
Demonstrated ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment
Demonstrated success in generation of actionable data to inform a go/no-decision point within a project/program
Experience with the safe handling of radioactive and biohazardous materials
Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels
Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.