Scientist - Biophysics
Apply NowCompany: Frontage Laboratories
Location: Exton, PA 19341
Description:
Scientist -Biophysics
Full Time, 6+ month contract/Temporary
Spring House, PA
Frontage Laboratories
Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Biologics
Frontage's biologics teams have an average of 10-15 years in complex drug development and have worked with large molecule applications throughout its evolution in product development. We can handle projects for a range of large molecule development projects including peptides, proteins, monoclonal antibodies, bispecific antibodies, biosimilars, oligonucleotides, biomarkers, and antibody drug conjugates.
Gain access to comprehensive biologics services in support of advanced development programs with Frontage's bioanalytical laboratory. We have the capabilities to analyze virtually any peptide, protein, or antibody, and have built a reputation for solving technical challenges related to assay development and validation.
CORE RESPONSIBILITIES:
1. Kinetics and affinity analysis of antigens and antibodies using Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI) and Kinetic Exclusion Assay (KinExA).
2. Perform HPLC analyses to assess the hydrophobicity, size, and purity of proteins.
3. Characterization of molecules using mass spectrometry (MS).
4. Data analysis, Documentation, and reporting - ELNs, LIMS etc.,
5. Lab instrument maintenance - cleaning spray sources and calibration weekly, prepping calibration solutions.
6. MS Lab specific supply maintenance - inventory and ordering.
7. Instrument and lab maintenance
May perform other duties as assigned.
OTHER RESPONSIBILITIES (if any):
1. Support assay development, validation, and bioanalysis efforts, as needed.
2. Assist in drafting and executing peer reviewed posters, manuscripts, tech reports and patent filings.
3. Attend in-house seminars to support team goals.
4. Present own work to members of department or external consultants as needed.
Experience/Special Skills:
Significant Safety or Working Considerations:
May work with potentially infectious samples of human and/or animal origin.
May handle hazardous chemicals.
Educational Requirements:
Ph.D. with 0-2 years of experience, or MS/BS with 3-5 years of experience in biochemistry, biophysics, immunology, molecular biology, analytical chemistry, or a related field.
Salary and Benefits:
Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
Full Time, 6+ month contract/Temporary
Spring House, PA
Frontage Laboratories
Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Biologics
Frontage's biologics teams have an average of 10-15 years in complex drug development and have worked with large molecule applications throughout its evolution in product development. We can handle projects for a range of large molecule development projects including peptides, proteins, monoclonal antibodies, bispecific antibodies, biosimilars, oligonucleotides, biomarkers, and antibody drug conjugates.
Gain access to comprehensive biologics services in support of advanced development programs with Frontage's bioanalytical laboratory. We have the capabilities to analyze virtually any peptide, protein, or antibody, and have built a reputation for solving technical challenges related to assay development and validation.
CORE RESPONSIBILITIES:
1. Kinetics and affinity analysis of antigens and antibodies using Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI) and Kinetic Exclusion Assay (KinExA).
2. Perform HPLC analyses to assess the hydrophobicity, size, and purity of proteins.
3. Characterization of molecules using mass spectrometry (MS).
4. Data analysis, Documentation, and reporting - ELNs, LIMS etc.,
5. Lab instrument maintenance - cleaning spray sources and calibration weekly, prepping calibration solutions.
6. MS Lab specific supply maintenance - inventory and ordering.
7. Instrument and lab maintenance
May perform other duties as assigned.
OTHER RESPONSIBILITIES (if any):
1. Support assay development, validation, and bioanalysis efforts, as needed.
2. Assist in drafting and executing peer reviewed posters, manuscripts, tech reports and patent filings.
3. Attend in-house seminars to support team goals.
4. Present own work to members of department or external consultants as needed.
Experience/Special Skills:
- Experience in Biophysical methods such (e.g., SPR, MS, HPLC) is required.
- Must have hands-on SPR experience.
- Solid understanding of protein biochemistry, binding affinity, thermodynamics, and antibody structure is preferred.
- Pharmaceutical experience with mass spectrometry characterization of antibodies is preferred. Experience analyzing biologics with chromatography methods (ex. HIC, SEC), including experience with common chromatography analysis platforms like Agilent or Empower preferred.
- Experience with lab automation preferred.
- Candidates must be highly organized, independent, and very detail oriented. Must be able to multitask and manage multiple projects, willing to learn new techniques, have great time management and communication skills.
Significant Safety or Working Considerations:
May work with potentially infectious samples of human and/or animal origin.
May handle hazardous chemicals.
Educational Requirements:
Ph.D. with 0-2 years of experience, or MS/BS with 3-5 years of experience in biochemistry, biophysics, immunology, molecular biology, analytical chemistry, or a related field.
Salary and Benefits:
Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.