Principal Scientist - Translational/Muscle Biologist

Make your mark for patients

We are seeking a Principal Scientist to join the US translational biology group based in Cambridge, MA and contribute to translational biology drug discovery efforts with an emphasis on muscle biology. The candidate will be responsible for leading projects, exploring new biology, designing, characterizing and deploying stem cell/3D models and other cellular/biochemical assays to be utilized in early drug discovery for multiple therapeutic programs and target discovery efforts. Collaborate in a matrixed team of scientists responsible for identification and knowledge building across pathobiological pathways and patient populations including those in neuromuscular disease related to nucleotide repeat expansions, genetic mutations, mitochondrial dysfunction or inflammation.

Please note: We are interested in every qualified candidate who is eligible to work in the United States. However, we are not able to sponsor visas at any point for this role. This includes taking over sponsorship for an existing Visa.

Base Salary: $137,600 to $180,600

Responsibilities:

• Team leadership: Supervise and mentor junior scientists, fostering a collaborative and innovative research environment.
• Project management: Oversee multiple projects, ensuring timely delivery of milestones and effective resource allocation.
• Innovation: Identify and implement new technologies and methodologies to advance muscle cell biology and translational research.
• Model Development: Design, characterize and validate primary cell or stem cell/3D models for therapeutic programs.
• Assay Execution: Conduct cell-based functional assays to characterize therapeutic hits or validate new targets that could require gene editing.
• Translational Assays: Perform complex assays (2D to 3D models) to enhance understanding of neuromuscular disease biology.
• Team Collaboration: Collaborate with cross-functional teams to integrate translational biology insights into therapeutic programs or new target proposals.
• Data Management: Document, analyze, and present data to internal teams.

Requirements

• PhD with 12+ years or MS Degree with 18+ years in drug discovery, biology, cellular biology, bioengineering or related field.

Competencies

• Deep knowledge in muscle biology, and translational assays.
• Strong assay development and drug discovery knowledge
• Strong track record of publishing in high-impact journals and presenting at scientific conferences
• Deep experience with mammalian cell culture, molecular and biochemical assays.
• Strong attention to detail, and enthusiasm for learning.
• Proven ability to lead projects, supervise and mentor scientists is a plus

Internal applicants should be in their current job for at least 12 months, must meet performance standards and are not on formal corrective/disciplinary process (PIP), warning, final warning, or compliance warning letters within the last 12 months. Please inform your Manager or your Talent Partner before applying to any internal job opportunities.

UCB is an equal opportunity employer. All qualified applicants will receive equal consideration for employment without regard to race/ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on US-Reasonable_Accommodation@ucb.com for application to US based roles. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.

Requisition ID: 89992

Recruiter: John Gasbarre

Hiring Manager: Jason Ekert

Talent Partner: Sandra Rogers

Job Level: MM II

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