Senior /Research Associate Scientist

Job Description

• The Drug Metabolism and Disposition group in QTAS has an open position for a Senior /Research Associate Senior /Research Associate Scientist
• Responsible for designing and conducting in vitro metID studies, processing the data, and interpreting MS/MS results.
• It is a fully drug metabolism laboratory-based role.
• Perform routine soft-spot identification studies and investigational vitro studies to address specific DMPK questions in drug discovery from lead optimization to candidate selection processes
• Develop a series of analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules
• Conduct in-depth analysis of Thermo Exploris 240/ QE LCMS/MS data by using Chemdraw, MassFrontier, Compound Discovere, Webmetabase platform
• Assume responsibility for maintaining laboratory equipment and maintain clear, detailed, and up-to-date experimental records
• Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department
• Maximize the experience at one of the best places to work environment at, with opportunities to network and learn from other professionals in adjacent fields

Qualifications:

• Bachelor`s degree in Chemistry, Analytical Chemistry, Biological Sciences and Biochemistry or related field with at least five years of hands-on, relevant drug metabolism/met ID lab experience working with a mass spectrometer.
• Master's degree in Organic Chemistry, Analytical Chemistry, Biochemistry with at least 3 years of experience.
• Hands on Lab experiences performing metabolic stability, CYP inhibition, and metabolite ID studies in liver subcellular fractions and hepatocytes preparing and analyzing samples from in vivo biological matrices using a mass spectrometer (LC-MS/MS)
• Strong consideration will be given to candidates proficient in using and troubleshooting a LC-MS/MS Thermo Exploris 240/ QE instrumentation, and handling Compound Discoverer or Webmetabase is a plus)
• Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing experiments while proactively seeking out senior personnel to discuss potential solutions to problems
• Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges
• Practical hands-on experience performing in vitro and in vivo biotransformation studies, liquid chromatography, mass spectrometry, structure elucidation/identification, fit-for purpose analytical method development including cross-species metabolite profiling.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance : Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.