Senior Research Associate, HTP Protein Production
Apply NowCompany: BioSpace
Location: Boston, MA 02115
Description:
Job Details
By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Objective / Purpose:
The role within the High-Throughput Protein Production Team under the Global Biologics Group is centered around advancing early therapeutic discovery using high-throughput techniques. This involves cloning, mammalian transfection, purification, and optimization utilizing the latest automation technologies. The position demands involvement in designing and executing experiments, data analysis, and strategy development for protein production and automation. Additionally, the role includes contributing to matrix project teams and facilitating collaboration with various therapeutic groups, requiring effective communication and adaptability in fast-paced environments.
Accountabilities
Education & Competencies
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range:
$86,500.00 - $135,960.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployee
Worker Sub-TypeRegular
Time TypeFull time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Objective / Purpose:
The role within the High-Throughput Protein Production Team under the Global Biologics Group is centered around advancing early therapeutic discovery using high-throughput techniques. This involves cloning, mammalian transfection, purification, and optimization utilizing the latest automation technologies. The position demands involvement in designing and executing experiments, data analysis, and strategy development for protein production and automation. Additionally, the role includes contributing to matrix project teams and facilitating collaboration with various therapeutic groups, requiring effective communication and adaptability in fast-paced environments.
Accountabilities
- Independently perform high throughput production of proteins in various formats, including antibody-based (mAbs, bispecific, VHHs, Fc-fusion, etc) and alternative formats to discover and advance novel therapeutics.
- Perform cloning, plasmid prep, transient expression, and purification of protein constructs using automated liquid handlers (Tecan, Hamilton, Dynamic Devices).
- Independently operate, edit, and troubleshoot program scripts for a variety of liquid handling robotic platforms.
- Perform mammalian cell culture work, including the maintenance of cell lines.
- Perform HTP analytics such as CE-SDS and aSEC.
- Evaluate and implement new methods for high throughput protein production.
- Perform data analysis and tracking using LIMS systems and maintain detailed ELN
- Summarize and communicate results at team meetings and contribute to scientific discussions.
- Troubleshoots complex problems and actively participates in innovation and/or optimization of established processes and workflows to ensure delivery on project goals
- Assist and share responsibilities on routine lab practices such as managing inventory and maintenance of equipment.
Education & Competencies
- MS in a scientific discipline (or equivalent) with 2+ years of relevant experience, or BS with 4+ years of relevant experience
- Minimum 2 years of industry experience
- Experience with protein production workflow in an industry setting is required
- Knowledge and hands-on experience in molecular cloning, protein expression and purification, and protein characterization are required
- Previous experience with the operation of laboratory automation is required
- Experience with mammalian cell culture, including CHO and HEK cell lines is required
- Previous experience in protein analyticals such as aSEC and CE-SDS is highly desirable
- Prior experience with LIMS, preferably GeneData Biologics is highly desirable
- Experience with molecular biology techniques and software such as SnapGene and Geneious Prime is a plus
- Excellent written and verbal communication and organization skills, along with the ability to work in cross-functional settings
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range:
$86,500.00 - $135,960.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployee
Worker Sub-TypeRegular
Time TypeFull time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.