Biologist - Neurodegeneration

Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Eli Lilly has a proud record of drug discovery and development for Alzheimer's Disease with a highly competitive portfolio of industry leading assets. We are now seeking highly motivated scientists to join the Neurodegeneration team to facilitate its mission of discovering novel medicines for the treatment of Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Parkinson's disease, and other related neurodegenerative conditions.

The Research Scientist will join the Boston Neurodegeneration group, which is part of the larger Lilly Neuroscience division. The ideal candidate is someone with a strong knowledge of disease mechanisms and cellular model systems for ALS. This role involves developing cellular models of ALS, employing induced-pluripotent stem cell (iPSc)-derived motor neurons or other cell lines, and using these models to assess potential therapeutic strategies and for profiling molecules with the goal of discovering novel treatments for ALS and potentially other neurodegenerative diseases. This is an exciting opportunity for a scientist who wants to develop their career in industry and make an impact on Lilly's effort to discover new treatments for patients.

Key responsibilities include but not limited to:

• Support projects developing novel therapeutic approaches for ALS focussing on TDP-43 biology.
• Develop, optimize, and implement cellular models of TDP-43 function and dysfunction as related to ALS.
• Culture and differentiation of human and patient iPSCs into motor neurons.
• Performing cellular assays suitable for high content imaging, including image analysis and measurement of biochemical or functional parameters.
• Genetic manipulation, including overexpression or knockdown of targets under investigation.
• Phenotypic characterisation of cells to identify and understand disease relevant pathways.
• Collaborate effectively with internal colleagues as part of a team to ensure effective progress of projects.
• Provide timely written and oral communication of work in lab reports and team meetings and more broadly to internal and external collaborators.
• Accurate recording of all practical work: completion of electronic lab notebook to Lilly procedure quality standards.
• Maintaining a tidy and efficient laboratory environment and ensuring health and safety standards are met.

Basic Qualifications:

• Masters Degree in neuroscience, cell biology, stem cell biology, biochemistry or a related scientific discipline, or a Bachelors degree in scientific discipline with 2+ years of work experience.

Additional Skills/Preferences:

• Solid background in neurodegenerative disease biology.
• Expertise in cell culture (including iPSC), characterization, banking, and differentiation into motor neurons.
• Strong lab skills in basic molecular biology (gel electrophoresis, Western blotting, RT-PCR, ELISA, etc), genetic manipulation (viral overexpression, target knockdown, or CRISPR editing).
• Sound knowledge of experimental design and statistics for biology experimental work.
• Understanding of biology lab safety requirements.
• Experience if high-content imaging, and image analysis.
• Ability to analyze, interpret and troubleshoot cell-based and biochemical assays.
• Capable of independently designing experiments, generating data, interpreting results, and documenting work.
• Strong organization skills, good time management and attention to detail.
• Ability to communicate effectively and report results accurately and in a timely manner.
• Demonstrated ability to work in a team-oriented environment.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$69,000 - $179,300

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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