Senior Research Scientist, Translational Medicine - Multiple Myeloma / Immuno-Oncology

We're here for one reason and one reason only - to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We've made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.

Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.

Job Description

Summary

The Senior Scientist will design and execute multi-omics biomarker analyses pertinent to multiple myeloma and other heme-oncology indications.

As a member of the Translational Medicine team, you will be at the intersection of Research and Clinical Development, providing valuable insight into the function and safety of CAR-T cells, the investigation of mechanisms of action, response, relapse and toxicity and the development of potential prognostic and predictive tools, supporting pipeline advancement and informing design of next generation therapeutics and clinical development of Kite's chimeric antigen receptor (CAR-T) programs.

Essential requirements are a solid understanding of cancer biology and immune therapy, a strong understanding and expertise with multi-omics analytical methods (eg scRNA-seq, Proteomics, Metabolomics, flow cytometry, Spatial transcriptomics) and downstream computational data processing, data interpretation and reporting, demonstrated by education, previous professional experience and authorship in high-impact scientific communications/publications. Familiarity with cloud computing platforms such as AWS and/or high-performance computing (HPC) environments is preferred.

Key Responsibilities:

• Collaborates with analytical teams within translational medicine and cross-functionally for planning and execution of correlative studies around disease biology, drug mechanisms of action and mechanisms of response, relapse, and toxicity.
• Oversees, directs, and establishes the computational analytical workflows.
• Writes, reviews, leads and/or contributes to research reports, and all project-related documents, as needed.
• Contributes and leads internal and external scientific presentation, discussions/collaborations, and publications, and engages with key internal stakeholders.
• Leverages cloud based or HPC infrastructure for scalable processing of large-scale multi-omics datasets.

Basic / Essential Qualifications

Bachelor's Degree and 8+ years of scientific experience

OR

Master's Degree and 6+ years of scientific experience

• Strong background in cancer biology and immuno-oncology and/or immunology (or closely related field)
• Strong understanding of clinical, translational, and mechanistic data
• Strong expertise in analysis of large multi-omics datasets, including proteomics, transcriptomics and other genomic analyses (eg scRNAseq, WES, ATACseq), using computational methods (eg R programing, Python) and Machine Learning to profile disease biology and immune cell repertoire.
• Strong collaboration, excellent interpersonal and communication skills
• Proficient with data presentations to communicate to a diverse cross-functional audience.
• Maintain a high degree of accuracy and attention to details.

Preferred Qualifications:

• Ph.D. degree in Immuno-oncology-related field (cancer biology, immunology, bioinformatics or a closely related field)
• Experience with cloud-based data storage, pipeline deployment, and computation using platforms such as AWS or HPC etc.
• Experience working with engineered T cells
• Understanding of early and/or late-stage drug and translational development process; including prior clinical trial experience in industry or academia
• Direct experience and/or in depth understanding of an array of analytical methods such as NGS methods, flow cytometry, ELISA or other ligand-based immune-assay, IHC/IF, dd-PCR, FISH.
• Comfortable in a matrixed and fast-paced company environment and able to adapt to changing priorities
• Understanding of clinical landscape, evolving therapy, competitive scenarios in the immune-oncology space
• Hands-on experience analyzing proteomics and/or metabolomics data sets is preferred.
• Familiarity with workflow management systems (e.g., Nextflow, Snakemake) and reproducible analysis tools (e.g., Docker, GitHub)

The salary range for this position is: $153,935.00 - $199,210.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

For jobs in the United States:

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Kite Pharma Employees and Contractors:

Please apply via the Internal Career Opportunities portal in Workday.