Antibody Discovery Scientist/Senior Scientist
Apply NowCompany: MOST
Location: San Jose, CA 95123
Description:
About Oxford BioTherapeutics
Oxford BioTherapeutics (OBT) is a dynamic, growing, international biotechnology company based in Oxford, UK, and San Jose, CA. We are a clinical stage oncology company with a pipeline of immunooncology and antibody-drug conjugate-based therapies. OBT's IO discovery process provides unique insight into the cancer-immune cell synapse and has identified several novel IO candidates for cancer therapy. Discovery of novel tumor antigens and immune cell surface proteins at OBT is performed using the proprietary Oxford Genome Anatomy Project (OGAP) database. OBT currently has one ADC in phase 1b clinical trials in collaboration with Menarini.
For further information, please see www.oxfordbiotherapeutics.com
Purpose of the Role
We are seeking an experienced Antibody Discovery Scientist to join our team. The primary focus of this role is to discover both tool & therapeutic antibodies using state-of-the-art in vivo and in vitro approaches. The ideal candidate will have multiple years of hands-on experience making antibodies and will set high standards for effective execution and rigorous thinking. A deep knowledge of antibody-based discovery and optimization/engineering approaches. You will use in vivo discovery, single B cell cloning and in vitro platforms to effectively mine antibody repertoires. In this role, recognizing and streamlining the most efficient work processes is key. It demands a high level of drive and motivation to not only achieve but surpass team and program objectives. Active engagement within the team and collaboration across groups are important for reaching optimal performance.
Essential Duties and Responsibilities:
Extensive experience in antibody discovery with both in vivo and in vitro discovery approaches
Extensive hands-on experience with DNA library design and construction, particularly with immune and affinity maturation libraries
Proficient with various display technologies such as phage, yeast or mammalian display
Skilled in library selection strategies. Experience with cell-based panning is a plus
Experience sorting antigen-specific memory B cells by FACS. Perform single-cell RT-PCR, PCR, molecular cloning, and BCR sequence analysis for antibody discovery
Experience with NGS and BCR repertoire analysis
Use surface plasmon resonance (SPR) to measure antibody kinetics and epitope binning
Analyze experimental data and prepare detailed reports and presentations
Extensive knowledge of B-cell immunology and antibody development
Work with cross-functional teams and contribute to project planning and strategy
Accountable for efficiently allocating team resources to ensure timely and effective progression of programs, with the potential to oversee and train more junior colleagues.
Please note the roles and responsibilities for the position include but are not limited to the above.
Knowledge, Experience, and Skills:
Ph.D. in Immunology, Molecular Biology, Biochemistry, Cell Biology or a related field. Master's degree with 8-10+ years of experience. Bachelor's degree with 10-12+ years of experience
Experience with antibody humanization techniques
Experience with FACS. We currently use a SONY cell sorter
Knowledgeable about sequence liabilities and antibody developability assessment
Experience making & validating antibodies specifically for IHC
Familiarity with data analysis software and statistical tools (e.g., FlowJo, SnapGene, Biacore, and GraphPad Prism)
An innovative, non-hierarchical approach that emphasizes approachability
Highly collaborative mindset with excellent communication skills essential for engaging with internal teams, ensuring high efficiency and transparency, and facilitating swift decision making
Strong presentation skills with the ability to present to both internal and external collaborators
Behaviors:
Highly self-motivated
Creative problem solver
Resilient
Proactive
Team oriented and supportive
A positive attitude
Enthusiastic
Flexible and agile
Readiness to learn new methods
One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits.
Benefits Offered:
Medical, dental and vision insurance
FSA (Flexible Spending Account)
STD, LTD, Basic Life, Supplemental Life and AD&D Insurance
401(k) Plan
Up to 120 hours of Paid Time Off in your first year (increasing with tenure)
5 sick days per year
11 paid holidays
Employee Referral Bonus Program
Annual training budget for professional development
Annual bonus program
New hire stock options
Team building events and activities
Equal Opportunities Statement
OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment.
Why Join Us
We promote a culture of innovation, responsibility, and commitment to our goals and objectives. Together, we believe, we can pool our resources and our uniqueness to develop novel, robust cures for one of the most challenging health conditions today. We recognize that our team is only as good as the people in it. Our people have used the words friendly, collaborative, and hard working to describe the culture here at OBT. This is why, while we strive to ensure that we hire only the best people. We also strive to provide a working environment that is based on cooperation, innovation, and mutual respect.
Oxford BioTherapeutics (OBT) is a dynamic, growing, international biotechnology company based in Oxford, UK, and San Jose, CA. We are a clinical stage oncology company with a pipeline of immunooncology and antibody-drug conjugate-based therapies. OBT's IO discovery process provides unique insight into the cancer-immune cell synapse and has identified several novel IO candidates for cancer therapy. Discovery of novel tumor antigens and immune cell surface proteins at OBT is performed using the proprietary Oxford Genome Anatomy Project (OGAP) database. OBT currently has one ADC in phase 1b clinical trials in collaboration with Menarini.
For further information, please see www.oxfordbiotherapeutics.com
Purpose of the Role
We are seeking an experienced Antibody Discovery Scientist to join our team. The primary focus of this role is to discover both tool & therapeutic antibodies using state-of-the-art in vivo and in vitro approaches. The ideal candidate will have multiple years of hands-on experience making antibodies and will set high standards for effective execution and rigorous thinking. A deep knowledge of antibody-based discovery and optimization/engineering approaches. You will use in vivo discovery, single B cell cloning and in vitro platforms to effectively mine antibody repertoires. In this role, recognizing and streamlining the most efficient work processes is key. It demands a high level of drive and motivation to not only achieve but surpass team and program objectives. Active engagement within the team and collaboration across groups are important for reaching optimal performance.
Essential Duties and Responsibilities:
Extensive experience in antibody discovery with both in vivo and in vitro discovery approaches
Extensive hands-on experience with DNA library design and construction, particularly with immune and affinity maturation libraries
Proficient with various display technologies such as phage, yeast or mammalian display
Skilled in library selection strategies. Experience with cell-based panning is a plus
Experience sorting antigen-specific memory B cells by FACS. Perform single-cell RT-PCR, PCR, molecular cloning, and BCR sequence analysis for antibody discovery
Experience with NGS and BCR repertoire analysis
Use surface plasmon resonance (SPR) to measure antibody kinetics and epitope binning
Analyze experimental data and prepare detailed reports and presentations
Extensive knowledge of B-cell immunology and antibody development
Work with cross-functional teams and contribute to project planning and strategy
Accountable for efficiently allocating team resources to ensure timely and effective progression of programs, with the potential to oversee and train more junior colleagues.
Please note the roles and responsibilities for the position include but are not limited to the above.
Knowledge, Experience, and Skills:
Ph.D. in Immunology, Molecular Biology, Biochemistry, Cell Biology or a related field. Master's degree with 8-10+ years of experience. Bachelor's degree with 10-12+ years of experience
Experience with antibody humanization techniques
Experience with FACS. We currently use a SONY cell sorter
Knowledgeable about sequence liabilities and antibody developability assessment
Experience making & validating antibodies specifically for IHC
Familiarity with data analysis software and statistical tools (e.g., FlowJo, SnapGene, Biacore, and GraphPad Prism)
An innovative, non-hierarchical approach that emphasizes approachability
Highly collaborative mindset with excellent communication skills essential for engaging with internal teams, ensuring high efficiency and transparency, and facilitating swift decision making
Strong presentation skills with the ability to present to both internal and external collaborators
Behaviors:
Highly self-motivated
Creative problem solver
Resilient
Proactive
Team oriented and supportive
A positive attitude
Enthusiastic
Flexible and agile
Readiness to learn new methods
One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits.
Benefits Offered:
Medical, dental and vision insurance
FSA (Flexible Spending Account)
STD, LTD, Basic Life, Supplemental Life and AD&D Insurance
401(k) Plan
Up to 120 hours of Paid Time Off in your first year (increasing with tenure)
5 sick days per year
11 paid holidays
Employee Referral Bonus Program
Annual training budget for professional development
Annual bonus program
New hire stock options
Team building events and activities
Equal Opportunities Statement
OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment.
Why Join Us
We promote a culture of innovation, responsibility, and commitment to our goals and objectives. Together, we believe, we can pool our resources and our uniqueness to develop novel, robust cures for one of the most challenging health conditions today. We recognize that our team is only as good as the people in it. Our people have used the words friendly, collaborative, and hard working to describe the culture here at OBT. This is why, while we strive to ensure that we hire only the best people. We also strive to provide a working environment that is based on cooperation, innovation, and mutual respect.