Senior Research Associate, DMPK

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

• Develop LC-MS/MS-based methods for quantification of compounds in various matrices (buffer, blood, plasma, tissue homogenates, etc) to support in vitro ADME, pharmacokinetic, and toxicokinetic studies.
• Develop high-resolution mass spectrometry (HRMS) methods for metabolite identification and profiling studies for preclinical and clinical samples.
• Perform mechanistic in vitro ADME assays, such as metabolic stability studies in various biological matrices (including hepatocytes, microsomes, blood, plasma, etc.).
• Perform data analysis, generate experimental reports, and present the data to teams; Archive raw data and finalized reports to electronic system and electronic notebook.
• Assist in the operation, maintenance, and troubleshooting of LC-MS/MS instruments.
• Ensure a safe and well-organized DMPK lab environment.

Required Skills, Experience, and Education:

• Bachelor/Master's degree in Pharmaceutical Sciences or a related scientific discipline, with 5+ of relevant industry experience or 3+ years of postgraduate working experience.
• Hands-on experience in operating and maintaining an LC-MS/MS system and/or a High-Resolution MS system.
• Hands-on experience in LC-MS method development for bioanalytical analysis and/or metabolite identification studies.
• Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS and/or HRMS analysis.
• Ability to conduct multiple laboratory and project tasks efficiently.
• Ability to work in a team-oriented environment with flexibility.
• Highly organized, detail-oriented, excellent record-keeping skills, and being able to adapt to a dynamic and fast-paced environment.
• Strong written and verbal communication skills, with a demonstrated ability to collaborate effectively in a team environment.

Preferred Skills:

• Hands-on experience in SCIEX QTRAP and/or Thermo Scientific Q Exactive mass spectrometers.
• Hands-on experience in HPLC/UPLC method development and/or bioanalytical method development in compliance with regulatory requirements.
• Working experience in DMPK lab.

The base salary range for this full-time position is $102,000 to $122,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

#LI-Hybrid #LI-CT1