Scientist, Process Development (Contract)

Senti Bio is seeking an experienced scientist to join our process development group for our cell therapy programs. A successful applicant will have prior experience with process development and scale up of gene modified cell therapies, hands on experience taking an early clinical stage cell therapy through late phase development, and be comfortable in a fast moving and nimble culture. Applicants should have current and extensive knowledge of culture expanded allogeneic cell products (e.g. NKs), comfort with pivotal stage process development, and GMP tech transfer to a CDMO experience. We are seeking individuals who are passionate about the future of "smart therapeutics" and have the energy and boldness to thrive and grow in a dynamic and fast startup environment.

Responsibilites

• Play a key role in process development for Senti's cell therapy development programs, with focus on culture expanded allogeneic products, including natural killer cells (NKs) and other therapeutic cell modalities.
• Work closely with the CDMO MSAT team to understand key requirements and guide decision making to enable seamless transfers and process optimizations.
• Develop internal capability for larger scale bioreactor-based generation of genetically modified cells suitable for transfer to a GMP facility.
• Maintain thought leadership with the current cell therapy ecosystem and bring best practices to the organization.
• Create process monitoring charts, support RCAs and occasionally be a person in plant.
• Coordinate tasks across multiple projects. Make decisions on prioritization and planning. Be the key driver to meet project timelines and milestones.
• Lead in design, development, and execution of process development studies to aid in optimization and characterization of cell manufacturing processes
• Apply knowledge of immune cell biology to establish process robustness
• Review executed batch records, extract and trend data, and identify areas for improvement
• Support regulatory filings through review of technical sections

Qualifications

• BS/BA degree with 6+ years experience or MS/PhD degree with 4+ years experience in a cell therapy development setting.
• 4+ years of cell therapy process development experience from proof-of-concept to clinical manufacturing, preferably with immunology cells (NKs, T, HSCs, etc.)
• Experience with lentiviral, retroviral, and other ex vivo cell engineering vectors a plus.
• Familiarity with IND regulatory requirements, GMP environments, and quality documentation.
• Demonstrated ability to work independently in a multi-functional project at a fast moving organization.
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Salary and Benefits

• The base hourly range for this role is $62-$70/hr. Starting pay is determined by multiple job-related factors including a candidate's skills, education and experience level, benchmark, and internal parity.
• Significant growth opportunity as the company expands.
• Empathetic, supportive, and collaborative colleagues and work environments