Principal Scientist, Structural Biology

At HotSpot, were not just looking for the brightest minds or for the most brilliant individual contributors. We want passionate team members who are comfortable adjusting their lens, arent afraid to think big, test bold ideas, and celebrate collective wins. We have established core values that resemble who we are and define our company culture. We are building a company where values drive everything we do inside and outside the organization.

#Courageous Adventurers #Leave your Mark #Keep it Human #Make it Real

RESPONSIBILITIES:

• Lead the scientific, technical, and operational aspects of structural biology for drug discovery programs
• Lead a multitude of efforts in parallel including X-ray crystallography, Cryo-EM, and NMR, each with a clear goal of delivering novel and iterative protein structure with small molecules to enable structure-based drug design and insight on MOA.
• Oversee a world class protein sciences team, supervising the design of protein constructs and protein production to support assay development and structural biology.
• Design structural biology strategies, such as protein engineering using rational design, fusion proteins, loop deletions, surface entropy reduction, mutagenesis, etc.
• Effectively interact with colleagues in biochemistry and biophysics, computational chemistry, medicinal chemistry, cell biology, and other functional groups to drive project progression.
• Manage external resources to ensure delivery of high-quality protein structural information, efficient recombinant protein design, protein expression, protein purification, crystallization, data collection and refinement.
• Devise and implement experiments to develop robust protocols to generate iterative co-complex structures, perform structural refinement with in-depth understanding of drug-protein interactions and articulate clearly detailed findings to the team.
• Demonstrated track record of accomplishments through use of strong problem-solving skills, as evidenced from strong peer-reviewed publication record
• Lead structure biology aspect of publication and poster presentations

QUALIFICATIONS:

• Ph.D. in structural biology or a related discipline with a demonstrated level of expertise, or equivalent. A minimum of 8+ years of relevant experience, including industry or a combination of post-doc and industry experience, is preferred.
• Extensive experience in solving protein structures using X-ray crystallography, cryo-EM and NMR; experience with small molecule allosteric inhibitors is a plus.
• Proven ability to design and troubleshoot protein constructs for crystallization, solve structures for technically challenging proteins, and elucidating co-structures of small molecules with target proteins.
• Demonstrated track record of success in structure-enabled drug discovery programs, as evidenced by a significant publication record in journals, patents and presentations
• Experience in using analytical/biophysical techniques (SEC-MALS, DLS, DSF, etc.) for assessing stability, solubility, and oligomerization status of proteins.
• Experience and willingness to occasionally perform biochemical/biophysical assay methods such as TR-FRET, AlphaLISA, FP, MST, MSD, etc., is a plus.
• Experience in managing CROs to solve problems and drive progress of the projects
• Exceptional interpersonal and communication skills, and the ability to work seamlessly with multiple drug discovery teams and provide structure related support at all stages of the project
• Strong organizational skills, ability to manage multiple projects simultaneously, and the capability to prioritize and focus on delivery of data for key decision making
• Efficient and comfortable with working remotely with teams at different locations
• Ability and willingness to learn and adopt emerging technologies to drug discovery process

OUR BENEFITS:

We believe that people are our greatest resource and foster a supportive environment that provides growth and development for all teammates. We recognize and reward performance and incentivizes long-term success. From benefits that focus on your health and well-being to competitive compensation to ownership in the company, we want to inspire our employees.

Our Benefits Include, But Are Not Limited To:

• Competitive salary and bonus plans
• New hire stock option award
• Comprehensive package of benefits plans and fringe benefits
• Generous paid holidays, time off, including 2 company wide shutdowns
• Flexible working arrangements; hybrid work model
• Amazing team of supportive colleagues