Senior Scientist I/II, In Vivo Pharmacology

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The In Vivo Pharmacology Department in South San Francisco has an opening for a Senior Scientist I or Senior Scientist II, with experience in in vivo pharmacology with a focus in development of innovative biologic antigen-directed therapeutics (Antibody, Antibody Drug Conjugates, etc.). This individual will support the strategy and coordination of operations of the team. The role will involve tumor model selection, study designs, hands-on in vivo data collection, analysis and presentations, as a representative member on project teams. The scientist will collaborate with in vitro biology, translational/biomarkers, toxicology, clinical research, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The ideal candidate will be highly motivated, work independently, collaborate with multi-disciplinary teams, with excellent communication skills, and have extensive skills in the field of oncology.

KEY RESPONSIBILITIES:

• Independently conceive and execute complex in vivo experiments utilizing tumor models in mice and approaches to enhance evaluation of novel therapeutics.
• Strategize, design, execute and analyze data from in vivo studies testing novel therapeutics, through efficacy/PK/tolerability, involving CDX, PDX, orthotopic models, etc. for various cancer types.
• Management of study operations within the team, including coordination of study designs and timelines/resources
• Effectively collaborates across intra and cross functional teams.
• Presents research findings to project teams/governance bodies and prepares technical reports.
• Works with external academic, biotechnology, and contract research organizations to advance our understanding of oncology diseases.
• Understands and adheres to IACUC protocols regarding animal welfare and handling.
• Mentors and guides one or more scientists in the group, evaluating and ensuring their effective performance. People-management responsibilities will be dependent on previous experience.

Qualifications

• Bachelor's Degree or equivalent education and typically, 10-12 years of experience, Master's Degree or equivalent education and typically 8-10 years of experience, PhD and typically 0-4 years of experience.
• Possess theoretical and practical experience of mouse oncology models, including CDX (required) and PDX models (preferred)
• Hands-on expertise to design and perform complex in vivo experiments utilizing tumor models in both immunocompetent and immunocompromised mice; proficient in cell/drug administration via different routes (SC, IP, PO, IV).
• Extensive knowledge of oncology and tumor biology with proven publication record.
• Excellent critical thinking skills in support of planning, execution and troubleshooting experiments.
• Strong organizational skills, attention to detail, and time-management skills enabling efficiency, productivity, and independence in research.
• Ability to manage and be accountable for multiple responsibilities and meet deadlines in a fast-paced environment.
• Strong, effective written and communication skills
• Demonstrate scientific leadership abilities and a collaborative personality.
• Flexibility with work schedule

Leveling of the position (I/II) will be decided based on the candidate qualifications

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• This job is eligible to participate in our long-term incentive programs

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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