Principal Scientist, Biomarker Laboratory, Next Generation Sequencing

BeiGene, Ltd. has proposed to change its name to BeOne Medicines Ltd. The new name is subject to shareholder approval and, once approved, use of the name will be phased in over 2025. There may be instances where "BeiGene" or "BeOne" are used to describe the company during this transition period. BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description:

We are seeking a highly motivated and experienced Principal Scientist to lead the development, validation, and execution of Next-Generation Sequencing (NGS) capabilities. This individual will play a key role in advancing our genomic analysis platforms to support clinical biomarker and translational research. The ideal candidate has in-depth technical expertise in NGS technologies and a strong background in molecular biology and bioinformatics, coupled with proven leadership in method development and scientific innovation in a clinical biomarker laboratory setting.

Essential Functions of the job:

• Drive the strategic design and implementation of new NGS workflows, including sample preparation, library preparation, sequencing, and data analysis pipelines.
• Develop and validate NGS-based assays in compliance with internal quality standards and relevant regulatory guidelines.
• Oversee and execute NGS-based clinical sample analysis for various applications (e.g., whole genome/exome sequencing, RNA-seq, cfDNA, targeted panels).
• Author and review method development and validation protocols, reports, and SOPs.
• Ensure quality control, data integrity, and timely delivery of analytical results.
• Collaborate with bioinformatics, clinical biomarker and operations, quality, and portfolio management teams to ensure robust and scalable solutions.
• Maintain accurate lab records and mentor junior scientists.

Supervisory Responsibilities:

• This role is initially an individual contributor. May supervise lab scientists as the team grows.

Computer Skills:

Proficiency in general software such as Microsoft Office (Word, Excel, PowerPoint), Outlook, Zoom, Teams as well as NGS task-related systems.

Other Qualifications:

• Demonstrated expertise in NGS platforms (e.g., Illumina, MGI) and associated wet-lab techniques.
• Hands-on experience in method development, validation and clinical sample analysis for NGS-based assays including but not limited to targeted panels, RNA-seq, cfDNA, single cell sequencing etc.
• Strong understanding of bioinformatics pipelines and data analysis principles.
• Proven analytical and problem-solving skills with the ability to think critically.
• Excellent communication, project management, and leadership skills.
• Experience in lab automation, electronic laboratory notebook (ELN), laboratory information management system (LIMS) and initial lab workflow set-up is a plus.

Education Required:

PhD in Molecular Biology, Genomics, Biochemistry, or related field with 3+ years of relevant experience (or MS with 5+ years).

Travel: Under 10%

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $135,800.00 - $180,800.00 annually
BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeiGene, Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer and we value diversity. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need.