Senior Scientist II, LC-MS/MS Small Molecule and Peptide In Vitro/In Vivo Bioanalysis

Job Details

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok .

Job Description

The Quantitative, Translational, and ADME Sciences (QTAS) Department at AbbVie is seeking a highly motivated and energetic bioanalytical SeniorScientist II to join the High-Throughput Automation Bioassay and Bioanalysis (HT-ABBA) group in North Chicago, IL. The main function of this position will be supporting LC-MS (Liquid Chromatography-Mass Spectrometry)-based bioanalysis, developing methods for Small Molecules and Peptides, and leading junior scientists. The ideal candidate will be experienced in development, optimization and implementation of LC-MS/MS bioanalytical methods to support In Vitro and pre-clinical In Vivo studies, as well as in managing junior scientists.

Responsibilities

• Research and develop bioanalytical LC-MS/MS based methods for quantifying small molecules and peptides in biofluids and tissues.
• Perform high-throughput quantitative bioanalysis for In Vitro assays, PK/PD and TK studies of small molecules and peptides in biological matrices.
• Operate and maintain LC-MS/MS and automated instruments. Identify and troubleshoot instruments as needed.
• Investigate, evaluate, and implement new methodologies, platforms, and technologies to meet challenging assay requirements and throughput while maintaining effective resource utilization.
• Act as the bio-analyst leader on multiple projects, interacting with collaborators and project team representatives to understand study impact, define project needs and priorities, and present work internally and externally.
• Manage and mentor junior scientists.
• Maintain electronic laboratory notebooks (ELN) and manage study documentation in theLaboratory Information Management System (LIMS).

Qualifications

• PhD (4+ years), M.S. (10+ years), or B.S. (12+ years) in analytical chemistry or related field with relevant pharmaceutical industry experience with a focus on bioanalysis and mass spectrometry.
• Strong LC-MS/MS method development background with direct experience in bioanalysis/assays and understanding of both experimental design and analytical practices required.
• Expertise with current high-throughput LC-MS/MS platforms (e.g., Leap autosamplers, Sciex API-6500/7500 triple quadrupoles), software (e.g., Sciex Analyst and/or OS, Electronic notebooks, LIMS, Discovery Quant) and automated sample preparation (e.g., Hamilton, Tecan Dispenser) platforms.
• Working experience with high resolution MS (TOF or orbitrap) and/or EchoMS for the bioanalysis of small molecules and peptides will be a plus.
• Working experience of regulated bioanalysis and/or CRO settings will be a plus.
• Excellent personal, verbal, and written communication skills.
• Highly organized with keen attention to detail, enabling effective independent work and success within a matrix team environment.
• Desire to excel in a fast-paced environment, with strong problem-solving skills, and theability to prioritize tasks and meet deadlines effectively.

Key Leadership Competencies

• Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance, proven ability to collaborate successfully across other groups within R&D.
• Creates a learning environment, open to suggestions and experiments to drive the science in the field of interest.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality, learns fast, grasps the essence and can change course quickly when needed.
• Raises the bar and is never satisfied with the status quo.
• Highly motivated and self-driven with the flexibility to quickly adapt to different projects.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentiveprograms.
• This job is eligible to participate in our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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